Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

Maria Karlgren, Anna Vildhede, Ulf Norinder, +5

Journal of Medicinal Chemistry

Transport KineticsMedicinal ChemistryDrug TargetProtein ExpressionPharmacological Study +13

Lower risk for cardiovascular mortality in oral 1 -hydroxy vitamin D3 users in a haemodialysis population

Takahiro Shoji, K. Shinohara, Emi Kimoto, +9

Nephrology Dialysis Transplantation

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Britton Boras, Rhys Jones, Brandon J. Anson, +49

Nature Communications

Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Hannah M. Jones, Hugh A. Barton, Yurong Lai, +8

Drug Metabolism and Disposition

Body fat mass and lean mass as predictors of survival in hemodialysis patients

Ryusuke Kakiya, Tetsuo Shoji, Yoshihiro Tsujimoto, +11

Kidney International

ObesityMetabolic SyndromeHemodialysisBody Fat MassBody Composition +9

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19

Britton Boras, Rhys Jones, Brandon J. Anson, +46

Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans

Heather Eng, Alyssa Dantonio, Eugene P. Kadar, +10

Drug Metabolism and Disposition

Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes

Emi Kimoto, Kenta Yoshida, Larissa M. Balogh, +5

Molecular Pharmaceutics

Oatp ProteinsImmunologyCellular PhysiologyGastrointestinal Peptide HormoneMembrane Transport +16

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

Manthena V. S. Varma, Yurong Lai, Emi Kimoto, +3

Pharmaceutical Research

Drug TargetBiochemistryEnzyme-mediated Drug-drug InteractionsMedicinePharmacology +4

Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs

Daiki Mori, Emi Kimoto, Brian Rago, +12

Clinical Pharmacology & Therapeutics