Concepedia

Translation Initiation Optimization

Translation Initiation Optimization is a methodological approach in molecular biology that specifically enhances the efficiency and accuracy of ribosome binding and start codon selection during gene expression to maximize recombinant protein yield.

39

Publications

2.9K

Citations

181

Authors

67

Institutions

Publications per year

2017–2026

12

Parents

Publications

39

Engineering circular RNA for enhanced protein production

Robert Chen, Sean K. Wang, Julia A. Belk et al. · Nature Biotechnology · 2022 · 424 citations · Full text

, , +17

Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency

Sang Woo Seo, Jae‐Seong Yang, Inhae Kim et al. · Metabolic Engineering · 2012 · 316 citations · Full text

, , +16

Evaluation of 244,000 synthetic sequences reveals design principles to optimize translation in Escherichia coli

Guillaume Cambray, Joao C. Guimaraes, Adam P. Arkin · Nature Biotechnology · 2018 · 251 citations

, , +14

Genome-Scale Analysis of Translation Elongation with a Ribosome Flow Model

Shlomi Reuveni, Isaac Meilijson, Martin Kupiec et al. · PLoS Computational Biology · 2011 · 204 citations · Full text

, , +15

Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines

Xuhua Xia · Vaccines · 2021 · 202 citations · Full text

, , +17

1–5 of 39

Authors

181

  1. JY
    Jae‐Seong Yang

    Pohang University of Science and Technology, South Korea

    2 publications · 395 citations

    2

    h-index

  2. AP
    Adam P. Arkin

    Lawrence Berkeley National Laboratory, United States

    2 publications · 287 citations

    2

    h-index

  3. GY
    Gyoo Yeol Jung

    Pohang University of Science and Technology, South Korea

    2 publications · 395 citations

    2

    h-index

  4. SK
    Sanguk Kim

    Pohang University of Science and Technology, South Korea

    2 publications · 395 citations

    2

    h-index

  5. JY
    Jina Yang

    Seoul National University, South Korea

    2 publications · 395 citations

    2

    h-index

1–5 of 181

Institutions

67

  1. Lawrence Berkeley National Laboratory

    Berkeley, United States

    4 h-index

    5 publications

    367 citations

  2. University of California, Berkeley

    Berkeley, United States

    4 h-index

    12 publications

    1K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    435 citations

  4. Pohang University of Science and Technology

    Pohang, South Korea

    2 h-index

    15 publications

    2.8K citations

  5. Xidian University

    Xi'an, China

    1 h-index

    3 publications

    39 citations

  6. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    1 publications

    204 citations

  7. Agency for Science, Technology and Research

    Singapore, Singapore

    1 h-index

    7 publications

    385 citations

  8. Max Planck Institute of Molecular Plant Physiology

    Potsdam, Germany

    1 h-index

    1 publications

    51 citations

1–8 of 67

Venues

  1. PubMed

    Repository · 4 publications · 303 citations

    4

    h-index

  2. ACS Synthetic Biology

    3 publications · 102 citations

    3

    h-index

  3. Gene

    2 publications · 61 citations

    2

    h-index

  4. Nature Biotechnology

    2 publications · 675 citations

    2

    h-index

  5. Protein Expression and Purification

    2 publications · 119 citations

    2

    h-index

1–5