Concepedia

Transition State Ensemble

Transition State Ensemble is a theoretical construct in protein folding dynamics that represents the ensemble of high-energy conformations at the top of the free energy barrier separating the unfolded and folded states, serving as the minimal energy pathway through which a protein transitions between folding intermediates.

224

Publications

17.1K

Citations

553

Authors

247

Institutions

Publications per year

2017–2026

26

Parents

Publications

224

Topological and energetic factors: what determines the structural details of the transition state ensemble and “en-route” intermediates for protein folding? an investigation for small globular proteins

Cecilia Clementi, Hugh Nymeyer, José N. Onuchic · Journal of Molecular Biology · 2000 · 1.3K citations

, , +17

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

Laura S. Itzhaki, Daniel E. Otzen, Alan R. Fersht · Journal of Molecular Biology · 1995 · 747 citations

, , +16

Reaction coordinates and rates from transition paths

Robert B. Best, Gerhard Hummer · Proceedings of the National Academy of Sciences · 2005 · 518 citations

, , +17

Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures

Eric J. Alm, David Baker · Proceedings of the National Academy of Sciences · 1999 · 397 citations

, , +17

Φ-Value analysis and the nature of protein-folding transition states

Alan R. Fersht, Satoshi Sato · Proceedings of the National Academy of Sciences · 2004 · 349 citations · Full text

, , +17

1–5 of 224

Authors

553

  1. JN
    José N. Onuchic

    Center for Theoretical Biological Physics, United States

    10 publications · 2.7K citations

    10

    h-index

  2. EI
    Eugene I. Shakhnovich

    Harvard University, United States

    10 publications · 629 citations

    10

    h-index

  3. PG
    Peter G. Wolynes

    Center for Theoretical Biological Physics, United States

    8 publications · 943 citations

    8

    h-index

  4. MV
    Michele Vendruscolo

    University of Cambridge, United Kingdom

    8 publications · 408 citations

    8

    h-index

  5. SD
    Steven D. Schwartz

    Albert Einstein College of Medicine, United States

    8 publications · 376 citations

    8

    h-index

1–5 of 553

Institutions

247

  1. University of Cambridge

    Cambridge, United Kingdom

    13 h-index

    35 publications

    2K citations

  2. Harvard University

    Cambridge, United States

    12 h-index

    27 publications

    1.6K citations

  3. University of California San Diego

    San Diego, United States

    12 h-index

    33 publications

    6.5K citations

  4. Center for Theoretical Biological Physics

    Houston, United States

    10 h-index

    34 publications

    2.9K citations

  5. University of Washington

    Seattle, United States

    9 h-index

    32 publications

    5.1K citations

  6. University of California, Berkeley

    Berkeley, United States

    9 h-index

    20 publications

    2.3K citations

  7. University of Maryland, College Park

    College Park, United States

    8 h-index

    17 publications

    987 citations

  8. University of Zurich

    Zurich, Switzerland

    7 h-index

    16 publications

    994 citations

1–8 of 247

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 43 publications · 5.7K citations

    39

    h-index

  2. The Journal of Chemical Physics

    28 publications · 1.6K citations

    21

    h-index

  3. The Journal of Physical Chemistry B

    18 publications · 690 citations

    16

    h-index

  4. Journal of Molecular Biology

    JMB · 17 publications · 3.3K citations

    15

    h-index

  5. Journal of the American Chemical Society

    JACS · 16 publications · 1K citations

    15

    h-index

1–5