Concepedia

Transgene Toxicity

Transgene Toxicity is an adverse biological response arising from the expression of a therapeutic transgene, distinguished from other gene therapy risks by its direct causation through the transgene product rather than the delivery vector or host immune reaction.

19

Publications

1.8K

Citations

150

Authors

71

Institutions

Publications per year

2017–2026

3

Parents

Publications

19

Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity

Christian Braun, Kaan Boztuǧ, Anna Paruzynski et al. · Science Translational Medicine · 2014 · 555 citations · Full text

, , +17

Comprehensive Analysis of the Acute Toxicities Induced by Systemic Administration of Cationic Lipid:Plasmid DNA Complexes in Mice

Jennifer D. Tousignant, Amy Gates, Laurie Ingram et al. · Human Gene Therapy · 2000 · 234 citations

, , +17

Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues

Dorothe Hameyer, Ate Loonstra, Leonid Eshkind et al. · Physiological Genomics · 2007 · 206 citations

, , +13

Real-Time Quantitative Reverse Transcriptase-Polymerase Chain Reaction as a Method for Determining Lentiviral Vector Titers and Measuring Transgene Expression

Gregory Lizée, Joeri L. Aerts, Monica I. Gonzales et al. · Human Gene Therapy · 2003 · 162 citations

, , +15

Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2,

Atsuko Y. Higashi, Tomokatsu Ikawa, Masamichi Muramatsu et al. · The Journal of Immunology · 2009 · 146 citations · Full text

, , +14

1–5 of 19

Authors

150

  1. MR
    Michael Rothe

    Medizinische Hochschule Hannover, Germany

    2 publications · 580 citations

    2

    h-index

  2. DP
    Donna Palmer

    Baylor College of Medicine, United States

    2 publications · 112 citations

    2

    h-index

  3. AS
    Axel Schambach

    Medizinische Hochschule Hannover, Germany

    2 publications · 580 citations

    2

    h-index

  4. NB
    Nicola Brunetti‐Pierri

    Telethon Institute Of Genetics And Medicine, Italy

    2 publications · 112 citations

    2

    h-index

  5. GS
    Gary Stapleton

    Baylor College of Medicine, United States

    1 publications · 87 citations

    1

    h-index

1–5 of 150

Institutions

71

  1. Medizinische Hochschule Hannover

    Hanover, Germany

    3 h-index

    13 publications

    5.6K citations

  2. National Institutes of Health

    Bethesda, United States

    2 h-index

    8 publications

    843 citations

  3. Ludwig-Maximilians-Universität München

    Munich, Germany

    2 h-index

    8 publications

    2.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    36 citations

  5. Baylor College of Medicine

    Houston, United States

    2 h-index

    18 publications

    1.1K citations

  6. National Cancer Institute

    Bethesda, United States

    2 h-index

    8 publications

    843 citations

  7. Amsterdam UMC Location University of Amsterdam

    Amsterdam, The Netherlands

    1 h-index

    1 publications

    206 citations

  8. Hôpitaux Universitaires Paris-Ouest

    Paris, France

    1 h-index

    3 publications

    75 citations

1–8 of 71

Venues

  1. Human Gene Therapy

    3 publications · 483 citations

    3

    h-index

  2. Stem Cells

    2 publications · 95 citations

    2

    h-index

  3. Advances in Space Research

    1 publications · 16 citations

    1

    h-index

  4. Regulatory Toxicology and Pharmacology

    RTP · 1 publications · 13 citations

    1

    h-index

  5. Nature

    1 publications · 78 citations

    1

    h-index

1–5