Concepedia

Transcriptomics-guided Engineering

Transcriptomics-Guided Engineering is a systems metabolic engineering approach that leverages genome-wide gene expression profiles to identify metabolic bottlenecks and regulatory targets, thereby rationally informing genetic modifications to optimize cellular phenotypes.

6

Publications

912

Citations

53

Authors

13

Institutions

Publications per year

2017–2026

3

Parents

Publications

6

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

David M. Valenzuela, Andrew Murphy, David Frendewey et al. · Nature Biotechnology · 2003 · 593 citations

, , +16

Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production

Shuobo Shi, Tao Chen, Zhigang Zhang et al. · Metabolic Engineering · 2009 · 117 citations

, , +17

A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells

Victor Tieu, Elena Sotillo, Jeremy Bjelajac et al. · Cell · 2024 · 113 citations · Full text

, , +17

Transcriptomics-Guided Design of Synthetic Promoters for a Mammalian System

Joseph K. Cheng, Hal S. Alper · ACS Synthetic Biology · 2016 · 32 citations

, , +17

Identification of metabolic engineering targets for improving glycerol assimilation ability of Saccharomyces cerevisiae based on adaptive laboratory evolution and transcriptome analysis

Kazuki Kawai, Yu Kanesaki, Hirofumi Yoshikawa et al. · Journal of Bioscience and Bioengineering · 2019 · 32 citations

, , +17

1–5 of 6

Authors

53

  1. XW
    Xiaorong Wang

    Sichuan Agricultural University, China

    1 publications · 593 citations

    1

    h-index

  2. HH
    Hong Hua Su

    Nanjing University of Aeronautics and Astronautics, China

    1 publications · 593 citations

    1

    h-index

  3. CF
    Chris Fisher

    Stanford University, United States

    1 publications · 113 citations

    1

    h-index

  4. JK
    Joseph K. Cheng

    The University of Texas at Austin, United States

    1 publications · 32 citations

    1

    h-index

  5. MM
    Meena Malipatlolla

    Stanford University, United States

    1 publications · 113 citations

    1

    h-index

1–5 of 53

Institutions

13

  1. Biotechnology Institute

    Washington D.C., United States

    1 h-index

    1 publications

    117 citations

  2. Technische Universität Dresden

    Dresden, Germany

    1 h-index

    1 publications

    593 citations

  3. Stanford University

    Stanford, United States

    1 h-index

    11 publications

    1.2K citations

  4. Regeneron (United States)

    Tarrytown, United States

    1 h-index

    25 publications

    14.8K citations

  5. Maastricht University

    Maastricht, The Netherlands

    1 h-index

    5 publications

    125 citations

  6. Tokyo Institute of Technology

    Tokyo, Japan

    1 h-index

    2 publications

    64 citations

  7. University of Minnesota

    Minneapolis, United States

    1 h-index

    1 publications

    117 citations

  8. Maastricht University Medical Centre

    Maastricht, The Netherlands

    1 h-index

    2 publications

    50 citations

1–8 of 13

Venues

  1. Biomaterials

    1 publications · 25 citations

    1

    h-index

  2. Nature Biotechnology

    1 publications · 593 citations

    1

    h-index

  3. Metabolic Engineering

    1 publications · 117 citations

    1

    h-index

  4. Cell

    1 publications · 113 citations

    1

    h-index

  5. ACS Synthetic Biology

    1 publications · 32 citations

    1

    h-index

1–5