David M. Valenzuela

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

Sue C. Bodine, Esther Latres, Susanne Baumhueter et al. · Science · 2001 · 3.4K citations · Full text

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard et al. · Cell · 2006 · 1.6K citations · Full text

Lifespan Extension, Chromatin, Genome Instability +10

Regulation of the Germinal Center Response by MicroRNA-155

To‐Ha Thai, Dinis Pedro Calado, Stefano Casola et al. · Science · 2007 · 1.5K citations

Individual Micrornas, Transcriptional Regulation, Developmental Biology +15

Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

David B. Lombard, Frederick W. Alt, Hwei-Ling Cheng et al. · Molecular and Cellular Biology · 2007 · 1.2K citations · Full text

Lifespan Extension, Systems Biology, Soluble Mitochondrial Protein +10

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

Marcia C. Haigis, Raúl Mostoslavsky, Kevin M. Haigis et al. · Cell · 2006 · 1.1K citations · Full text

Caloric Restriction, Metabolic Syndrome, Energy Homeostasis +11