Concepedia

Tim-4 Receptor Function

TIM-4 Receptor Function is a phagocytic receptor mechanism that specifically mediates the recognition and binding of phosphatidylserine exposed on apoptotic cells, thereby enabling their clearance by macrophages and dendritic cells without eliciting an inflammatory response.

38

Publications

4K

Citations

320

Authors

124

Institutions

Publications per year

2017–2026

13

Parents

Publications

38

Identification of Tim4 as a phosphatidylserine receptor

Masanori Miyanishi, Kazutoshi Tada, Masato Koike et al. · Nature · 2007 · 1.2K citations

, , +7

TIM-4 is the ligand for TIM-1, and the TIM-1–TIM-4 interaction regulates T cell proliferation

Jennifer Hartt Meyers, Sumone Chakravarti, David H. Schlesinger et al. · Nature Immunology · 2005 · 373 citations

, , +8

T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells

Rosemarie H. DeKruyff, Xia Bu, Ángela Ballesteros et al. · The Journal of Immunology · 2010 · 331 citations · Full text

, , +13

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

Roselynn Rodriguez‐Manzanet, Miguel A. F. Sanjuán, Henry Yim Wu et al. · Proceedings of the National Academy of Sciences · 2010 · 182 citations · Full text

, , +17

Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity

Andrew Chow, Sara Schad, Michael D. Green et al. · Cancer Cell · 2021 · 175 citations · Full text

, , +14

1–5 of 38

Authors

320

  1. RH
    Rosemarie H. DeKruyff

    Stanford University, United States

    5 publications · 901 citations

    5

    h-index

  2. GJ
    Gordon J. Freeman

    Dana-Farber Cancer Institute, United States

    4 publications · 528 citations

    4

    h-index

  3. DT
    Dale T. Umetsu

    Stanford University, United States

    4 publications · 837 citations

    4

    h-index

  4. VK
    Vijay K. Kuchroo

    Brigham and Women's Hospital, United States

    3 publications · 661 citations

    3

    h-index

  5. SE
    Sarah E. Umetsu

    University of California, San Francisco, United States

    3 publications · 506 citations

    3

    h-index

1–5 of 320

Institutions

124

  1. Harvard University

    Cambridge, United States

    7 h-index

    51 publications

    7.6K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    4 h-index

    16 publications

    1.6K citations

  3. Brigham and Women's Hospital

    Boston, United States

    4 h-index

    30 publications

    4.8K citations

  4. Boston Children's Hospital

    Boston, United States

    3 h-index

    20 publications

    2.9K citations

  5. Stanford University

    Stanford, United States

    3 h-index

    15 publications

    1.9K citations

  6. Shandong University

    Jinan, China

    3 h-index

    31 publications

    852 citations

  7. The University of Osaka

    Osaka, Japan

    3 h-index

    7 publications

    2.7K citations

  8. Nanjing Medical University

    Nanjing, China

    2 h-index

    4 publications

    246 citations

1–8 of 124

Venues

  1. The Journal of Immunology

    JI · 5 publications · 592 citations

    5

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 500 citations

    4

    h-index

  3. Cell Reports

    2 publications · 44 citations

    2

    h-index

  4. Journal of Virology

    JVI · 2 publications · 98 citations

    2

    h-index

  5. Current Biology

    1 publications · 158 citations

    1

    h-index

1–5