Concepedia

Thiolation Domain Function

Thiolation Domain Function is a biochemical mechanism within nonribosomal peptide synthetase (NRPS) systems that serves to covalently bind activated amino acid or peptidyl intermediates via a thioester linkage to a phosphopantetheine arm, thereby enabling their translocation between catalytic domains during peptide assembly.

30

Publications

1.6K

Citations

120

Authors

40

Institutions

Publications per year

2017–2026

9

Parents

Publications

30

Identification and Characterization of the Echinocandin B Biosynthetic Gene Cluster from Emericella rugulosa NRRL 11440

Ralph A. Cacho, Wei Jiang, Yit‐Heng Chooi et al. · Journal of the American Chemical Society · 2012 · 144 citations · Full text

, , +17

Ebony, a Novel Nonribosomal Peptide Synthetase for β-Alanine Conjugation with Biogenic Amines in Drosophila

Arnd Richardt, Tobias Kemme, Stefanie Wagner et al. · Journal of Biological Chemistry · 2003 · 141 citations · Full text

, , +12

Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases

Torsten Stachelhaus, Anja Hüser, Mohamed A. Marahiel · Chemistry & Biology · 1996 · 132 citations · Full text

, , +6

The EntF and EntE adenylation domains of <i>Escherichia coli</i> enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates

David E. Ehmann, Cathryn A. Shaw-Reid, Heather C. Losey et al. · Proceedings of the National Academy of Sciences · 2000 · 110 citations

, , +17

Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Mark J. Calcott, Jeremy G. Owen, David F. Ackerley · Nature Communications · 2020 · 104 citations · Full text

, , +13

1–5 of 30

Authors

120

  1. CT
    Christopher T. Walsh

    Harvard University, United States

    9 publications · 641 citations

    9

    h-index

  2. MA
    Mohamed A. Marahiel

    Philipps University of Marburg, Germany

    4 publications · 417 citations

    4

    h-index

  3. SG
    Sylvie Garneau‐Tsodikova

    University of Kentucky, United States

    3 publications · 54 citations

    3

    h-index

  4. DS
    Dirk Schwarzer

    University of Tübingen, Germany

    2 publications · 197 citations

    2

    h-index

  5. SM
    Shogo Mori

    University of Kentucky, United States

    2 publications · 27 citations

    2

    h-index

1–5 of 120

Institutions

40

  1. Harvard University

    Cambridge, United States

    9 h-index

    30 publications

    2.1K citations

  2. Philipps University of Marburg

    Marburg, Germany

    5 h-index

    14 publications

    1.4K citations

  3. University of Kentucky

    Lexington, United States

    3 h-index

    12 publications

    235 citations

  4. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    6 publications

    398 citations

  5. Maurice Wilkins Centre

    Auckland, New Zealand

    2 h-index

    4 publications

    339 citations

  6. Max Planck Institute for Terrestrial Microbiology

    Marburg, Germany

    2 h-index

    10 publications

    808 citations

  7. Victoria University of Wellington

    Wellington, New Zealand

    2 h-index

    5 publications

    366 citations

  8. Stanford University

    Stanford, United States

    2 h-index

    6 publications

    258 citations

1–8 of 40

Venues

  1. Biochemistry

    4 publications · 182 citations

    5

    h-index

  2. Journal of the American Chemical Society

    JACS · 4 publications · 297 citations

    4

    h-index

  3. ChemBioChem

    3 publications · 150 citations

    3

    h-index

  4. Chemistry & Biology

    3 publications · 230 citations

    3

    h-index

  5. Nature Communications

    2 publications · 132 citations

    2

    h-index

1–5