Concepedia

Therapy-driven Clonal Sweeps

Therapy-Driven Clonal Sweeps is a biological phenomenon in cancer evolution wherein a therapeutic intervention selectively promotes the expansion of a dominant resistant clone, thereby reducing intratumoral heterogeneity through the competitive displacement of sensitive subclones.

3

Publications

1.4K

Citations

104

Authors

23

Institutions

Publications per year

2017–2026

1

Parents

Publications

3

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Kelly L. Bolton, Ryan Ptashkin, Teng Gao et al. · Nature Genetics · 2020 · 741 citations · Full text

, , +16

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

Hyo-Eun Carrie Bhang, David A. Ruddy, Viveksagar Krishnamurthy Radhakrishna et al. · Nature Medicine · 2015 · 527 citations

, , +16

Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia

Jitka Malčíková, Kateřina Staňo Kozubík, Boris Tichý et al. · Leukemia · 2014 · 145 citations · Full text

, , +17

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma

Jacob Househam, Eszter Lakatos, Tahel Ronel et al. · Nature Cancer · 2025 · 12 citations · Full text

, , +17

1–4 of 3

Authors

104

  1. LZ
    Lior Z. Braunstein

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 741 citations

    1

    h-index

  2. AP
    Akshar Patel

    Stanford University, United States

    1 publications · 741 citations

    1

    h-index

  3. ZK
    Zsofia K. Stadler

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 741 citations

    1

    h-index

  4. LB
    Laura Boucai

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 741 citations

    1

    h-index

  5. WR
    William R. Sellers

    Dana-Farber Cancer Institute, United States

    1 publications · 527 citations

    1

    h-index

1–5 of 104

Institutions

23

  1. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    4 publications

    2.5K citations

  2. Harvard University

    Cambridge, United States

    1 h-index

    2 publications

    1.1K citations

  3. Addenbrooke's Hospital

    Cambridge, United Kingdom

    1 h-index

    1 publications

    741 citations

  4. Cancer Research And Biostatistics

    Seattle, United States

    1 h-index

    2 publications

    1.1K citations

  5. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    1 h-index

    1 publications

    741 citations

  6. Moffitt Cancer Center

    Tampa, United States

    1 h-index

    3 publications

    2.2K citations

  7. Central European Institute of Technology

    Brno, Czechia

    1 h-index

    13 publications

    1.9K citations

  8. Dana-Farber/Harvard Cancer Center

    Boston, United States

    1 h-index

    2 publications

    1.1K citations

1–8 of 23

Venues

  1. Nature Medicine

    1 publications · 527 citations

    1

    h-index

  2. Nature Genetics

    1 publications · 741 citations

    1

    h-index

  3. Leukemia

    1 publications · 145 citations

    1

    h-index

  4. Nature Cancer

    1 publications · 12 citations

1–4