Concepedia

Tau Sumoylation

Tau sumoylation is a post-translational modification in which small ubiquitin-like modifier (SUMO) proteins are covalently attached to specific lysine residues on the microtubule-associated protein tau, thereby altering its stability, subcellular localization, and aggregation propensity in the context of neurodegenerative tauopathies.

15

Publications

1.2K

Citations

115

Authors

54

Institutions

Publications per year

2017–2026

6

Parents

Publications

15

Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein

Véronique Dorval, Paul E. Fraser · Journal of Biological Chemistry · 2006 · 307 citations · Full text

, , +14

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

Hongbin Luo, Yiyuan Xia, Xiji Shu et al. · Proceedings of the National Academy of Sciences · 2014 · 227 citations · Full text

, , +17

Sumoylation of amyloid precursor protein negatively regulates Aβ aggregate levels

Yu-Qian Zhang, Kevin D. Sarge · Biochemical and Biophysical Research Communications · 2008 · 113 citations · Full text

, , +14

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Israel Hernández, Gabriel Luna, Jennifer N. Rauch et al. · Science Translational Medicine · 2019 · 102 citations · Full text

, , +16

Enhanced SUMOylation in polyglutamine diseases

Hiroko Ueda, Jun Goto, Hideji Hashida et al. · Biochemical and Biophysical Research Communications · 2002 · 81 citations

, , +12

1–5 of 15

Authors

115

  1. PE
    Paul E. Fraser

    University of Toronto, Canada

    3 publications · 345 citations

    3

    h-index

  2. XW
    Xiaochuan Wang

    Huazhong University of Science and Technology, China

    3 publications · 284 citations

    3

    h-index

  3. HL
    Honglian Li

    Huazhong University of Science and Technology, China

    2 publications · 57 citations

    2

    h-index

  4. QW
    Qun Wang

    East China Normal University, China

    2 publications · 57 citations

    2

    h-index

  5. JW
    Jian–Zhi Wang

    Huazhong University of Science and Technology, China

    2 publications · 244 citations

    2

    h-index

1–5 of 115

Institutions

54

  1. Huazhong University of Science and Technology

    Wuhan, China

    4 h-index

    38 publications

    3.6K citations

  2. Nantong University

    Nantong, China

    4 h-index

    6 publications

    585 citations

  3. University of Toronto

    Toronto, Canada

    3 h-index

    4 publications

    366 citations

  4. Jianghan University

    Wuhan, China

    2 h-index

    3 publications

    261 citations

  5. Icahn School of Medicine at Mount Sinai

    New York, United States

    2 h-index

    2 publications

    119 citations

  6. European Brain Research Institute

    Rome, Italy

    2 h-index

    2 publications

    48 citations

  7. Sapienza University of Rome

    Rome, Italy

    2 h-index

    2 publications

    48 citations

  8. Occupational Cancer Research Centre

    Toronto, Canada

    2 h-index

    3 publications

    59 citations

1–8 of 54

Venues

  1. Neuroscience Letters

    2 publications · 133 citations

    2

    h-index

  2. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 194 citations

    2

    h-index

  3. Molecular Neurobiology

    1 publications · 21 citations

    1

    h-index

  4. Journal of Biological Chemistry

    JBC · 1 publications · 307 citations

    1

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 227 citations

    1

    h-index

1–5