Concepedia

Targeted Gene Insertion

Targeted Gene Insertion is a genome integration strategy that directs the precise insertion of exogenous genetic material into a predetermined genomic locus through site-specific recombination or homology-directed repair mechanisms, distinguishing it from random integration approaches by ensuring controlled genomic context and positional consistency.

290

Publications

39.2K

Citations

1.7K

Authors

502

Institutions

Publications per year

2017–2026

83

Variants

Site-specific Gene IntegrationTargeted Integration

Parents

Publications

290

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

Andrea H. Brand, Norbert Perrimon · Development · 1993 · 9.8K citations

, , +17

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Shankar Srinivas, Tomoko Watanabe, Chyuan‐Sheng Lin et al. · BMC Developmental Biology · 2001 · 3.2K citations · Full text

, , +15

Disruption of the <i>Dictyostelium</i> Myosin Heavy Chain Gene by Homologous Recombination

Arturo De Lozanne, James A. Spudich · Science · 1987 · 992 citations

, , +17

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

Frederick L. Moolten · PubMed · 1986 · 972 citations

, , +16

P[acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in <i>D. melanogaster</i>

Koen J. T. Venken, Yuchun He, Roger A. Hoskins et al. · Science · 2006 · 856 citations · Full text

, , +17

1–5 of 290

Authors

1.7K

  1. MR
    Mario R. Capecchi

    University of Utah, United States

    5 publications · 830 citations

    5

    h-index

  2. ZI
    Zoltán Ivics

    Paul Ehrlich Institut, Germany

    4 publications · 292 citations

    4

    h-index

  3. BL
    Brian Lenderts

    Corteva (United States), United States

    4 publications · 278 citations

    4

    h-index

  4. OS
    Oliver Smithies

    University of North Carolina at Chapel Hill, United States

    4 publications · 328 citations

    4

    h-index

  5. LB
    L. B. Crittenden

    U.S. National Poultry Research Center, United States

    3 publications · 157 citations

    3

    h-index

1–5 of 1.7K

Institutions

502

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    33 publications

    25.7K citations

  2. National Institutes of Health

    Bethesda, United States

    12 h-index

    55 publications

    6.5K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    56 publications

    4.1K citations

  4. Inserm

    Paris, France

    10 h-index

    25 publications

    1.2K citations

  5. Chinese Academy of Sciences

    Beijing, China

    8 h-index

    48 publications

    3.2K citations

  6. National Cancer Institute

    Bethesda, United States

    7 h-index

    29 publications

    3.4K citations

  7. Baylor College of Medicine

    Houston, United States

    6 h-index

    19 publications

    4.8K citations

  8. Stanford University

    Stanford, United States

    6 h-index

    27 publications

    3.1K citations

1–8 of 502

Venues

  1. Nucleic Acids Research

    18 publications · 1.5K citations

    17

    h-index

  2. Molecular and Cellular Biology

    MCB · 14 publications · 1.3K citations

    14

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 13 publications · 2.8K citations

    13

    h-index

  4. PLoS ONE

    14 publications · 903 citations

    12

    h-index

  5. Science

    9 publications · 3.4K citations

    9

    h-index

1–5