Concepedia

Target-based Phenotypic Analysis

Target-Based Phenotypic Analysis is a systematic methodological framework in reverse chemical genetics that identifies and characterizes phenotypic outcomes resulting from the modulation of a predefined molecular target, distinguishing it from conventional phenotypic screening by its reliance on target-centric validation and mechanistic causality.

4

Publications

443

Citations

29

Authors

10

Institutions

Publications per year

2017–2026

1

Parents

Publications

4

Identifying the proteins to which small-molecule probes and drugs bind in cells

Shao‐En Ong, Monica Schenone, Adam A. Margolin et al. · Proceedings of the National Academy of Sciences · 2009 · 307 citations · Full text

, , +16

The Contribution of Mechanistic Understanding to Phenotypic Screening for First-in-Class Medicines

David C. Swinney · SLAS DISCOVERY · 2013 · 70 citations · Full text

, , +11

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

Rosa M. Reguera, Raquel Álvarez‐Velilla, Rafael Balaña‐Fouce · International Journal for Parasitology Drugs and Drug Resistance · 2014 · 49 citations · Full text

, , +14

A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus

Xiujuan Zhao, Yanyan Wang, Qinghua Cui et al. · Viruses · 2019 · 17 citations · Full text

, , +12

1–4 of 4

Authors

29

  1. LR
    Lijun Rong

    University of Illinois Chicago, United States

    1 publications · 17 citations

    1

    h-index

  2. LK
    Letian Kuai

    WuXi AppTec (China), China

    1 publications · 307 citations

    1

    h-index

  3. XW
    Xiang Wang

    Sichuan University, China

    1 publications · 307 citations

    1

    h-index

  4. XZ
    Xiujuan Zhao

    Sun Yat-sen University, China

    1 publications · 17 citations

    1

    h-index

  5. QC
    Qinghua Cui

    Shandong University of Traditional Chinese Medicine, China

    1 publications · 17 citations

    1

    h-index

1–5 of 29

Institutions

10

  1. Universidad de León

    León, Spain

    1 h-index

    4 publications

    196 citations

  2. University of Illinois Chicago

    Chicago, United States

    1 h-index

    1 publications

    17 citations

  3. Institute of Oceanology

    Qingdao, China

    1 h-index

    1 publications

    17 citations

  4. Abterra Biosciences (United States)

    San Diego, United States

    1 h-index

    1 publications

    307 citations

  5. Colorado State University

    Fort Collins, United States

    1 h-index

    1 publications

    307 citations

  6. Institute for Rare and Neglected Diseases Drug Discovery

    Mountain View, United States

    1 h-index

    1 publications

    70 citations

  7. Shandong University of Traditional Chinese Medicine

    Jinan, China

    1 h-index

    7 publications

    119 citations

  8. Broad Institute

    Cambridge, United States

    1 h-index

    1 publications

    307 citations

1–8 of 10

Venues

  1. 1

    h-index

  2. SLAS DISCOVERY

    1 publications · 70 citations

    1

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 307 citations

    1

    h-index

  4. Viruses

    1 publications · 17 citations

    1

    h-index

1–4