Concepedia

Talin-integrin Activation

Talin-Integrin Activation is a molecular mechanism in cell adhesion signaling wherein the cytoskeletal protein talin binds to and induces a conformational change in integrin receptors, thereby increasing their affinity for extracellular matrix ligands and facilitating focal adhesion complex assembly during cancer cell migration and metastasis.

144

Publications

15.8K

Citations

693

Authors

251

Institutions

Publications per year

2017–2026

37

Parents

Publications

144

Stretching Single Talin Rod Molecules Activates Vinculin Binding

Armando E. del Río Hernández, Raúl Pérez‐Jiménez, Ruchuan Liu et al. · Science · 2009 · 1.5K citations · Full text

, , +17

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

Seiji Tadokoro, Sanford J. Shattil, Koji Eto et al. · Science · 2003 · 1.2K citations

, , +16

Structural Basis of Integrin Activation by Talin

Kate L. Wegener, Anthony W. Partridge, Jaewon Han et al. · Cell · 2007 · 667 citations · Full text

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Structural Determinants of Integrin Recognition by Talin

Begoña García‐Álvarez, José M. de Pereda, David Calderwood et al. · Molecular Cell · 2003 · 520 citations · Full text

, , +14

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

Xian Zhang, Guoying Jiang, Yunfei Cai et al. · Nature Cell Biology · 2008 · 485 citations · Full text

, , +16

1–5 of 144

Authors

693

  1. MH
    Mark H. Ginsberg

    University of California San Diego, United States

    19 publications · 4.4K citations

    18

    h-index

  2. DR
    David R. Critchley

    University of Leicester, United Kingdom

    12 publications · 2.3K citations

    11

    h-index

  3. JQ
    Jun Qin

    Cleveland Clinic, United States

    10 publications · 1.3K citations

    10

    h-index

  4. ID
    Iain D. Campbell

    University of Oxford, United Kingdom

    9 publications · 2K citations

    9

    h-index

  5. DC
    David Calderwood

    Yale University, United States

    9 publications · 2.5K citations

    9

    h-index

1–5 of 693

Institutions

251

  1. University of California San Diego

    San Diego, United States

    19 h-index

    95 publications

    12.2K citations

  2. University of Leicester

    Leicester, United Kingdom

    12 h-index

    39 publications

    6.7K citations

  3. University of Oxford

    Oxford, United Kingdom

    10 h-index

    34 publications

    6.1K citations

  4. Yale University

    New Haven, United States

    9 h-index

    22 publications

    2.1K citations

  5. Max Planck Institute of Biochemistry

    Martinsried, Germany

    9 h-index

    27 publications

    4.5K citations

  6. Scripps Research Institute

    San Diego, United States

    9 h-index

    30 publications

    12.6K citations

  7. Cleveland Clinic Lerner College of Medicine

    Cleveland, United States

    6 h-index

    30 publications

    3.8K citations

  8. Cleveland Clinic

    Cleveland, United States

    5 h-index

    31 publications

    3.9K citations

1–8 of 251

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 1.9K citations

    15

    h-index

  2. The Journal of Cell Biology

    JCB · 9 publications · 1.1K citations

    9

    h-index

  3. PLoS ONE

    5 publications · 242 citations

    5

    h-index

  4. Journal of Cell Science

    4 publications · 403 citations

    4

    h-index

  5. PubMed

    Repository · 4 publications · 150 citations

    4

    h-index

1–5