Concepedia

T Cell Degranulation

T Cell Degranulation is a cellular mechanism, belonging to the class of effector functions in adaptive immunity, wherein cytotoxic T lymphocytes release lytic granules containing perforin and granzymes at the immunological synapse to induce target cell apoptosis.

82

Publications

5.9K

Citations

588

Authors

213

Institutions

Publications per year

2017–2026

18

Parents

Publications

82

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Xuefang Cao, Sheng F. Cai, Todd A. Fehniger et al. · Immunity · 2007 · 989 citations · Full text

, , +15

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

Giovanna Bossi, Gillian M. Griffiths · Nature Medicine · 1999 · 380 citations

, , +13

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway

S Isaaz, Kristin Baetz, Kristin J. Olsen et al. · European Journal of Immunology · 1995 · 226 citations

, , +15

Detection of T-Cell Degranulation: CD107a and b

Michael R. Betts, Richard A. Koup · Methods in cell biology · 2004 · 218 citations

, , +11

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

Kerry Dobbs, Cecilia Domínguez Conde, Shen‐Ying Zhang et al. · New England Journal of Medicine · 2015 · 200 citations · Full text

, , +13

1–5 of 82

Authors

588

  1. MR
    Michael R. Betts

    University of Pennsylvania, United States

    2 publications · 379 citations

    2

    h-index

  2. KS
    Kimberly Shafer-Weaver

    Science Applications International Corporation (United States), United States

    2 publications · 74 citations

    2

    h-index

  3. AM
    Anatoli Malyguine

    Science Applications International Corporation (United States), United States

    2 publications · 74 citations

    2

    h-index

  4. TM
    Toshio Morikawa

    Kyoto Pharmaceutical University, Japan

    2 publications · 154 citations

    2

    h-index

  5. MS
    Micah S. Kerr

    Indiana University – Purdue University Indianapolis, United States

    2 publications · 108 citations

    2

    h-index

1–5 of 588

Institutions

213

  1. Inserm

    Paris, France

    7 h-index

    40 publications

    2.6K citations

  2. National Institutes of Health

    Bethesda, United States

    4 h-index

    9 publications

    1.1K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    10 publications

    644 citations

  4. The University of Melbourne

    Melbourne, Australia

    4 h-index

    17 publications

    899 citations

  5. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    16 publications

    672 citations

  6. Karolinska University Hospital

    Stockholm, Sweden

    3 h-index

    14 publications

    528 citations

  7. Université Paris Cité

    Paris, France

    3 h-index

    17 publications

    1.5K citations

  8. Kyoto Pharmaceutical University

    Kyoto, Japan

    3 h-index

    12 publications

    958 citations

1–8 of 213

Venues

  1. The Journal of Immunology

    JI · 10 publications · 885 citations

    10

    h-index

  2. Journal of Virology

    JVI · 4 publications · 358 citations

    4

    h-index

  3. PLoS ONE

    3 publications · 236 citations

    3

    h-index

  4. Journal of Allergy and Clinical Immunology

    3 publications · 96 citations

    3

    h-index

  5. European Journal of Immunology

    EJI · 3 publications · 331 citations

    3

    h-index

1–5