Concepedia

Synapse Pruning

Synapse Pruning is a developmental neurobiological process in which excess synaptic connections between neurons are selectively eliminated to refine neural circuits, distinct from other synaptic modifications by its role in reducing rather than strengthening or forming connections.

111

Publications

17.2K

Citations

704

Authors

252

Institutions

Publications per year

2017–2026

47

Parents

Publications

111

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa Chiara Paolicelli, Giulia Bolasco, Francesca Pagani et al. · Science · 2011 · 4.2K citations

, , +17

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

Guomei Tang, Kathryn Gudsnuk, Sheng‐Han Kuo et al. · Neuron · 2014 · 1.2K citations · Full text

, , +10

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Carl M. Sellgren, Jessica Gracias, Bradley Watmuff et al. · Nature Neuroscience · 2019 · 828 citations

, , +16

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Laetitia Weinhard, Giulia Di Bartolomei, Giulia Bolasco et al. · Nature Communications · 2018 · 801 citations · Full text

, , +17

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Hansen Lui, Jiasheng Zhang, Stefanie Ritter Makinson et al. · Cell · 2016 · 736 citations · Full text

, , +12

1–5 of 111

Authors

704

  1. BS
    Beth Stevens

    Boston Children's Hospital, United States

    4 publications · 985 citations

    4

    h-index

  2. CT
    Cornelius T. Gross

    European Molecular Biology Laboratory, Italy

    3 publications · 5.1K citations

    3

    h-index

  3. ER
    Eytan Ruppin

    Tel Aviv University, Israel

    3 publications · 369 citations

    3

    h-index

  4. BA
    Ben A. Barres

    Stanford University, United States

    3 publications · 1.6K citations

    3

    h-index

  5. IM
    Isaac Meilijson

    Tel Aviv University, Israel

    3 publications · 369 citations

    3

    h-index

1–5 of 704

Institutions

252

  1. Harvard University

    Cambridge, United States

    10 h-index

    33 publications

    12.4K citations

  2. Stanford University

    Stanford, United States

    8 h-index

    27 publications

    4.9K citations

  3. Broad Institute

    Cambridge, United States

    6 h-index

    10 publications

    1.4K citations

  4. Boston Children's Hospital

    Boston, United States

    5 h-index

    23 publications

    5K citations

  5. University of California, Irvine

    Irvine, United States

    5 h-index

    19 publications

    1.8K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    7 publications

    972 citations

  7. RIKEN Center for Brain Science

    Wako, Japan

    5 h-index

    9 publications

    363 citations

  8. Columbia University

    New York, United States

    4 h-index

    12 publications

    1.2K citations

1–8 of 252

Venues

  1. Journal of Neuroscience

    8 publications · 859 citations

    8

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 438 citations

    4

    h-index

  3. Neuron

    4 publications · 1.7K citations

    4

    h-index

  4. Nature Communications

    3 publications · 975 citations

    3

    h-index

  5. Science

    3 publications · 5K citations

    3

    h-index

1–5