Superantigen Recognition is a molecular immunological mechanism characterized by the unconventional binding of microbial superantigens to major histocompatibility complex class II molecules and T-cell receptors outside their typical antigen-binding regions, resulting in polyclonal T-cell activation and excessive cytokine release.
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Superantigens interact with MHC class II molecules outside of the antigen groove
Paolo Dellabona, Jean Peccoud, John W. Kappler et al. · Cell · 1990 · 429 citations
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