Concepedia

Super Elongation Complex

The Super Elongation Complex is a multi-subunit protein complex that regulates RNA polymerase II elongation by recruiting positive transcription elongation factor b (P-TEFb) and other elongation factors to specific genomic loci, thereby facilitating the transition of paused polymerase into productive transcriptional elongation.

70

Publications

4.1K

Citations

485

Authors

161

Institutions

Publications per year

2017–2026

44

Parents

Publications

70

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

Zichong Li, Jia Guo, Yuntao Wu et al. · Nucleic Acids Research · 2012 · 309 citations · Full text

, , +17

Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein

Koen Bartholomeeusen, Yanhui Xiang, Koh Fujinaga et al. · Journal of Biological Chemistry · 2012 · 204 citations · Full text

, , +16

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

Nanhai He, Caleb K. Chan, Bijan Sobhian et al. · Proceedings of the National Academy of Sciences · 2011 · 197 citations

, , +16

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

Kaiwei Liang, Xin Gao, Joshua M. Gilmore et al. · Molecular and Cellular Biology · 2015 · 195 citations · Full text

, , +16

The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

Zhuojuan Luo, Chengqi Lin, Erin Guest et al. · Molecular and Cellular Biology · 2012 · 193 citations · Full text

, , +15

1–5 of 70

Authors

485

  1. QZ
    Qiang Zhou

    University of California, Berkeley, United States

    15 publications · 1.2K citations

    15

    h-index

  2. ZL
    Zichong Li

    University of California, Berkeley, United States

    8 publications · 691 citations

    8

    h-index

  3. AS
    Ali Shilatifard

    Northwestern University, United States

    7 publications · 753 citations

    7

    h-index

  4. CL
    Chengqi Lin

    Southeast University, China

    6 publications · 554 citations

    6

    h-index

  5. YX
    Yuhua Xue

    Xiamen University, China

    6 publications · 395 citations

    6

    h-index

1–5 of 485

Institutions

161

  1. University of California, Berkeley

    Berkeley, United States

    17 h-index

    61 publications

    5.6K citations

  2. Xiamen University

    Xiamen, China

    13 h-index

    41 publications

    2.5K citations

  3. Sichuan University

    Chengdu, China

    6 h-index

    50 publications

    1.1K citations

  4. Stowers Institute for Medical Research

    Kansas City, United States

    5 h-index

    40 publications

    5.4K citations

  5. Northwestern University

    Evanston, United States

    5 h-index

    40 publications

    1.5K citations

  6. Baylor College of Medicine

    Houston, United States

    5 h-index

    31 publications

    1.4K citations

  7. University of California, San Francisco

    San Francisco, United States

    5 h-index

    12 publications

    1.3K citations

  8. Southeast University

    Nanjing, China

    4 h-index

    29 publications

    1.3K citations

1–8 of 161

Venues

  1. Nucleic Acids Research

    7 publications · 648 citations

    7

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 460 citations

    6

    h-index

  3. Nature Communications

    6 publications · 199 citations

    6

    h-index

  4. Cell Reports

    5 publications · 206 citations

    5

    h-index

  5. Molecular and Cellular Biology

    MCB · 5 publications · 463 citations

    5

    h-index

1–5