Concepedia

Substrate-mediated Activation

Substrate-Mediated Activation is a biochemical mechanism in which the binding of a substrate to an enzyme induces a conformational change that enhances the enzyme's catalytic activity, distinguishing it from other forms of enzyme activation by directly linking activation to substrate binding rather than allosteric effectors or covalent modifications.

181

Publications

10K

Citations

688

Authors

254

Institutions

Publications per year

2017–2026

38

Parents

Publications

181

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva et al. · Cell · 2012 · 903 citations · Full text

, , +16

Substrate-specific Activation of Sirtuins by Resveratrol

Matt Kaeberlein, Thomas McDonagh, Birgit Heltweg et al. · Journal of Biological Chemistry · 2005 · 742 citations · Full text

, , +15

The Dendrimer Effect in Homogeneous Catalysis

Brett A. Helms, Jean M. J. Fréchet · Advanced Synthesis & Catalysis · 2006 · 360 citations

, , +17

Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis

John‐Paul J. Yu, J.S. Brunzelle, Gert N. Moll et al. · Science · 2006 · 306 citations

, , +14

Theoretical Study on the Mechanism of the Oxygen Activation Process in Cysteine Dioxygenase Enzymes

Devesh Kumar, Walter Thiel, Sam P. de Visser · Journal of the American Chemical Society · 2011 · 213 citations

, , +16

1–5 of 181

Authors

688

  1. PM
    Patrick Masson

    Service de Santé des Armées, France

    5 publications · 316 citations

    5

    h-index

  2. FJ
    Frank Jordan

    Rutgers, The State University of New Jersey, United States

    5 publications · 116 citations

    5

    h-index

  3. TF
    Torgeir Flatmark

    University of Bergen, Norway

    3 publications · 200 citations

    3

    h-index

  4. HL
    Haijuan Li

    Changchun Institute of Applied Chemistry, China

    3 publications · 67 citations

    3

    h-index

  5. WF
    William Furey

    University of Pittsburgh, United States

    3 publications · 104 citations

    3

    h-index

1–5 of 688

Institutions

254

  1. Rutgers, The State University of New Jersey

    New Brunswick, United States

    7 h-index

    26 publications

    783 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    23 publications

    3.2K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    24 publications

    870 citations

  4. Heidelberg University

    Heidelberg, Germany

    4 h-index

    10 publications

    596 citations

  5. Service de Santé des Armées

    Metz, France

    4 h-index

    11 publications

    766 citations

  6. Australian National University

    Canberra, Australia

    4 h-index

    17 publications

    539 citations

  7. Medical College of Wisconsin

    Milwaukee, United States

    3 h-index

    10 publications

    390 citations

  8. University of California, Berkeley

    Berkeley, United States

    3 h-index

    5 publications

    940 citations

1–8 of 254

Venues

  1. Biochemistry

    22 publications · 1K citations

    19

    h-index

  2. Journal of Biological Chemistry

    JBC · 15 publications · 1.5K citations

    14

    h-index

  3. Journal of the American Chemical Society

    JACS · 9 publications · 699 citations

    9

    h-index

  4. European Journal of Biochemistry

    EJB · 9 publications · 461 citations

    9

    h-index

  5. Biochemical Journal

    BJ · 6 publications · 310 citations

    6

    h-index

1–5