Subclonal Architecture

Subclonal Architecture is the spatial and phylogenetic organization of genetically distinct subpopulations within a tumor, distinguished by their evolutionary relationships and mutational divergence from the founding clone.

Publications

17.1K

Citations

804

Authors

258

Institutions

Publications per year

2017–2026

Parents

Tumor Heterogeneity

Children

Ancestral Clone ReconstructionBulk Tumor SequencingClonal Sweep DynamicsDriver Mutation TimingMinimal Residual Disease ClonalityMultiregion SequencingNeutral Evolution In TumorsSubclonal Copy Number VariationSubclonal PhylogenyTumor Cell Population Structure

Publications

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Christina Curtis, Sohrab P. Shah, Suet‐Feung Chin et al. · Nature · 2012 · 6.4K citations · Full text

Life Sciences, Genetics, Oncology +14

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah, Andrew Roth, Rodrigo Goya et al. · Nature · 2012 · 2K citations

Medicine, Molecular Biology, Oncology +14

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

Dan A. Landau, Scott L. Carter, Petar Stojanov et al. · Cell · 2013 · 1.4K citations · Full text

Medicine, Genetics, Molecular Genetics +14

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

Lucy Yates, Moritz Gerstung, Stian Knappskog et al. · Nature Medicine · 2015 · 840 citations · Full text

Medicine, Molecular Biology, Oncology +16

SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution

Christopher A. Miller, Brian S. White, Nathan D. Dees et al. · PLoS Computational Biology · 2014 · 495 citations · Full text

Medicine, Cancer Biology, Oncology +17

1–5 of 68

Authors

804

TA
Trevor A. Graham
Queen Mary University of London, United Kingdom
6 publications · 747 citations
6
h-index
AS
Andrea Sottoriva
Institute of Cancer Research, United Kingdom
6 publications · 747 citations
6
h-index
PJ
Peter J. Campbell
Wellcome Sanger Institute, United Kingdom
5 publications · 1.6K citations
5
h-index
TH
Timon Heide
Institute of Cancer Research, United Kingdom
5 publications · 710 citations
5
h-index
BW
Benjamin Werner
Institute of Cancer Research, United Kingdom
4 publications · 651 citations
4
h-index

1–5 of 804

Institutions

258

1–8 of 258

Venues

Nature Communications
9 publications · 828 citations
9
h-index
Nature
5 publications · 9.1K citations
5
h-index
bioRxiv (Cold Spring Harbor Laboratory)
Repository · 4 publications · 114 citations
4
h-index
Genome biology
3 publications · 408 citations
3
h-index
PLoS Computational Biology
3 publications · 586 citations
3
h-index

1–5