Concepedia

Structure-guided Allosteric Engineering

Structure-Guided Allosteric Engineering is a computational and experimental methodology within protein engineering that utilizes high-resolution structural data to rationally design allosteric sites or modulate allosteric pathways in proteins, thereby enabling precise control over protein function through targeted conformational perturbations.

7

Publications

200

Citations

56

Authors

21

Institutions

Publications per year

2017–2026

6

Parents

Publications

7

Allosteric cooperation in a de novo-designed two-domain protein

Fabio Pirro, Nathan W. Schmidt, James Lincoff et al. · Proceedings of the National Academy of Sciences · 2020 · 55 citations · Full text

, , +17

Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform

Brandon E. Aubol, Kendra L. Hailey, Laurent Fattet et al. · Journal of Molecular Biology · 2017 · 36 citations

, , +14

Structure-guided design of antibacterials that allosterically inhibit DNA gyrase

Reema K. Thalji, Kaushik Raha, Daniele Andreotti et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 35 citations · Full text

, , +14

Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities

Martin Schröder, Li Tan, Jinhua Wang et al. · Cell chemical biology · 2020 · 26 citations · Full text

, , +17

Conservation and Diversity in Allosteric Fingerprints of Proteins for Evolutionary-inspired Engineering and Design

Wei-Ven Tee, Zhen Wah Tan, Enrico Guarnera et al. · Journal of Molecular Biology · 2022 · 22 citations

, , +13

1–5 of 7

Authors

56

  1. LL
    Lijun Liu

    University of California, San Francisco, United States

    1 publications · 55 citations

    1

    h-index

  2. PA
    Patricia A. Jennings

    University of California San Diego, United States

    1 publications · 36 citations

    1

    h-index

  3. GQ
    Geoffrey Quinque

    GlaxoSmithKline (United Kingdom), United Kingdom

    1 publications · 35 citations

    1

    h-index

  4. AC
    Anna Checchia

    GlaxoSmithKline (Italy), Italy

    1 publications · 35 citations

    1

    h-index

  5. ZW
    Zhen Wah Tan

    National University of Singapore, Singapore

    1 publications · 22 citations

    1

    h-index

1–5 of 56

Institutions

21

  1. Hillsborough Hospital

    Charlottetown, Canada

    1 h-index

    1 publications

    13 citations

  2. Whitehead Institute for Biomedical Research

    Cambridge, United States

    1 h-index

    1 publications

    13 citations

  3. GlaxoSmithKline (United States)

    Philadelphia, United States

    1 h-index

    10 publications

    350 citations

  4. University of California, San Francisco

    San Francisco, United States

    1 h-index

    5 publications

    275 citations

  5. Bioinformatics Institute

    Singapore, Singapore

    1 h-index

    4 publications

    88 citations

  6. National University of Singapore

    Singapore, Singapore

    1 h-index

    1 publications

    22 citations

  7. Shanghai Institute of Organic Chemistry

    Shanghai, China

    1 h-index

    1 publications

    26 citations

  8. Peking University

    Beijing, China

    1 h-index

    1 publications

    55 citations

1–8 of 21

Venues

  1. Journal of Molecular Biology

    JMB · 3 publications · 71 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 55 citations

    1

    h-index

  3. Cell chemical biology

    1 publications · 26 citations

    1

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    1 publications · 35 citations

    1

    h-index

  5. Physical Biology

    1 publications · 13 citations

    1

    h-index

1–5