Concepedia

Steroid Scaffold Modification

Steroid Scaffold Modification is a chemical strategy that entails the systematic alteration of the core cyclopentanoperhydrophenanthrene framework of steroids to generate novel derivatives with optimized biological activity, physicochemical properties, or metabolic stability.

80

Publications

2.7K

Citations

383

Authors

111

Institutions

Publications per year

2017–2026

17

Parents

Publications

80

Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

Ralf Thoma, Tanja Schulz‐Gasch, Brigitte D’Arcy et al. · Nature · 2004 · 353 citations

, , +13

Structure-activity relationships of topically active steroids: the selection of fluticasone propionate

G. H. Phillipps · Respiratory Medicine · 1990 · 197 citations

, , +14

Novel modified steroid derivatives of androstanolone as chemotherapeutic anti-cancer agents

Mohamed El‐Far, Gamal A. Elmegeed, Emad F. Eskander et al. · European Journal of Medicinal Chemistry · 2009 · 85 citations

, , +11

Concise Enantioselective Synthesis of Oxygenated Steroids via Sequential Copper(II)-Catalyzed Michael Addition/Intramolecular Aldol Cyclization Reactions

Nathan R. Cichowicz, Will Kaplan, Yaroslav Khomutnyk et al. · Journal of the American Chemical Society · 2015 · 78 citations · Full text

, , +13

Novel and Potent 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Harshani R. Lawrence, Nigel Vicker, G.M. Allan et al. · Journal of Medicinal Chemistry · 2005 · 60 citations · Full text

, , +17

1–5 of 80

Authors

383

  1. GA
    Gamal A. Elmegeed

    National Research Centre, Egypt

    3 publications · 120 citations

    3

    h-index

  2. RA
    Regina A. Tuktarova

    Institute of Catalysis and Petrochemistry, Russia

    3 publications · 44 citations

    3

    h-index

  3. VA
    Vladimir A. D’yakonov

    Institute of Catalysis and Petrochemistry, Russia

    3 publications · 44 citations

    3

    h-index

  4. MA
    Mohamed A. Tantawy

    National Research Centre, Egypt

    2 publications · 102 citations

    2

    h-index

  5. EA
    Evgenija A. Djurendić

    University of Novi Sad, Serbia

    2 publications · 60 citations

    2

    h-index

1–5 of 383

Institutions

111

  1. Institute of Catalysis and Petrochemistry

    Ufa, Russia

    3 h-index

    11 publications

    168 citations

  2. Central Drug Research Institute

    Lucknow, India

    3 h-index

    13 publications

    360 citations

  3. National Research Centre

    Giza, Egypt

    3 h-index

    13 publications

    497 citations

  4. Oregon State University

    Corvallis, United States

    2 h-index

    4 publications

    62 citations

  5. Mansoura University

    Al Mansurah, Egypt

    2 h-index

    3 publications

    137 citations

  6. National Academy of Sciences of Belarus

    Minsk, Belarus

    2 h-index

    6 publications

    166 citations

  7. The University of Tokyo

    Tokyo, Japan

    2 h-index

    3 publications

    97 citations

  8. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    10 publications

    173 citations

1–8 of 111

Venues

  1. Steroids

    15 publications · 345 citations

    12

    h-index

  2. Tetrahedron Letters

    8 publications · 177 citations

    8

    h-index

  3. Tetrahedron

    5 publications · 143 citations

    5

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    4 publications · 73 citations

    5

    h-index

  5. European Journal of Medicinal Chemistry

    4 publications · 176 citations

    4

    h-index

1–5