Concepedia

Steric Tolerance

Steric Tolerance is a structural property in medicinal chemistry that refers to the extent to which a molecular site can accommodate spatial perturbations without significantly compromising biological activity, distinguishing it from related steric descriptors by quantifying permissible volumetric deviation in bioisosteric substitutions.

301

Publications

12.9K

Citations

1.2K

Authors

308

Institutions

Publications per year

2017–2026

27

Parents

Publications

301

Highly Active Palladium Catalysts for Suzuki Coupling Reactions

John P. Wolfe, Robert A. Singer, Bryant H. Yang et al. · Journal of the American Chemical Society · 1999 · 1.1K citations

, , +16

Synthesis and Antiinflammatory Activity of Coumarin Derivatives<sup>,</sup>

Christos Kontogiorgis, Dimitra Hadjipavlou‐Litina · Journal of Medicinal Chemistry · 2005 · 427 citations · Full text

, , +15

Structural basis of albumin–thyroxine interactions and familial dysalbuminemic hyperthyroxinemia

I. Petitpas, Charles E. Petersen, Chung‐Eun Ha et al. · Proceedings of the National Academy of Sciences · 2003 · 258 citations

, , +17

Supramolecular Control on Chemo- and Regioselectivity via Encapsulation of (NHC)-Au Catalyst within a Hexameric Self-Assembled Host

Alessandra Cavarzan, Alessandro Scarso, Paolo Sgarbossa et al. · Journal of the American Chemical Society · 2011 · 221 citations

, , +17

Intramolecular Free‐Radical Reactions

K. Heusler, J. Kalvoda · Angewandte Chemie International Edition in English · 1964 · 219 citations

, , +12

1–5 of 301

Authors

1.2K

  1. HC
    Herbert C. Brown

    Purdue University West Lafayette, United States

    11 publications · 260 citations

    10

    h-index

  2. MN
    M. NAKAGAWA

    The University of Osaka, Japan

    3 publications · 42 citations

    3

    h-index

  3. MD
    Michael D. Ward

    New York University, United States

    3 publications · 157 citations

    3

    h-index

  4. FD
    Francesca Di Bianca

    University of Palermo, Italy

    3 publications · 112 citations

    3

    h-index

  5. PW
    Peng Wu

    East China Normal University, China

    3 publications · 226 citations

    3

    h-index

1–5 of 1.2K

Institutions

308

  1. Cornell University

    Ithaca, United States

    5 h-index

    12 publications

    1.1K citations

  2. East China Normal University

    Shanghai, China

    5 h-index

    27 publications

    2K citations

  3. Scripps Research Institute

    San Diego, United States

    5 h-index

    23 publications

    809 citations

  4. Hebrew University of Jerusalem

    Jerusalem, Israel

    5 h-index

    8 publications

    265 citations

  5. University of Amsterdam

    Amsterdam, The Netherlands

    5 h-index

    15 publications

    1K citations

  6. University of Southampton

    Southampton, United Kingdom

    4 h-index

    14 publications

    496 citations

  7. University of British Columbia

    Vancouver, Canada

    4 h-index

    12 publications

    323 citations

  8. Carl von Ossietzky Universität Oldenburg

    Oldenburg, Germany

    3 h-index

    9 publications

    254 citations

1–8 of 308

Venues

  1. Journal of the American Chemical Society

    JACS · 27 publications · 2.7K citations

    21

    h-index

  2. Journal of Medicinal Chemistry

    16 publications · 1.1K citations

    16

    h-index

  3. The Journal of Organic Chemistry

    JOC · 21 publications · 831 citations

    16

    h-index

  4. Inorganic Chemistry

    15 publications · 799 citations

    15

    h-index

  5. Organometallics

    16 publications · 542 citations

    15

    h-index

1–5