Stem Cell Initiation is a theoretical construct in cancer biology that identifies the malignant transformation of normal stem cells as the originating event in tumorigenesis, distinguished from other initiation models by implicating stem cells rather than differentiated or progenitor cells as the primary targets of oncogenic mutations.
88
Publications
8.3K
Citations
544
Authors
199
Institutions
Publications per year
2017–2026
18
Parents
Publications
88
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
Andrei V. Krivtsov, David Twomey, Zhaohui Feng et al. · Nature · 2006 · 1.5K citations
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
Brian Zambrowicz, Glenn A. Friedrich, Eric C. Buxton et al. · Nature · 1998 · 438 citations
1–5 of 88
Authors
544
- JM
2
h-index
- SE
2
h-index
- MB
2
h-index
- AW
2
h-index
- GQ
2
h-index
1–5 of 544
Institutions
199
Harvard University
Cambridge, United States
5 h-index
5 publications
1.7K citations
Howard Hughes Medical Institute
Chevy Chase, United States
5 h-index
11 publications
4.4K citations
Dana-Farber Cancer Institute
Boston, United States
4 h-index
6 publications
1.7K citations
Hebrew University of Jerusalem
Jerusalem, Israel
3 h-index
13 publications
898 citations
Center for Cancer Research
Bethesda, United States
3 h-index
17 publications
460 citations
Case Western Reserve University
Cleveland, United States
3 h-index
8 publications
760 citations
Thomas Jefferson University
Philadelphia, United States
3 h-index
3 publications
252 citations
Brigham and Women's Hospital
Boston, United States
3 h-index
5 publications
1.7K citations
1–8 of 199
Venues
- Cell stem cell
4 publications · 417 citations
4
h-index
- Nature
4 publications · 2.9K citations
4
h-index
- PubMed
Repository · 4 publications · 215 citations
4
h-index
- Cancer Research
3 publications · 372 citations
3
h-index
- Proceedings of the National Academy of Sciences
PNAS · 3 publications · 859 citations
3
h-index
1–5