Concepedia

Somatic Hypermutation Fidelity

Somatic Hypermutation Fidelity is a molecular genetic metric that quantifies the accuracy of antibody gene mutations during somatic hypermutation by measuring the ratio of intended, functional mutations to off-target or erroneous alterations within the immunoglobulin loci.

16

Publications

2.8K

Citations

151

Authors

77

Institutions

Publications per year

2017–2026

1

Parents

Publications

16

Comprehensive Analysis of Hypermutation in Human Cancer

Brittany Campbell, Nicholas Light, David Fabrizio et al. · Cell · 2017 · 796 citations · Full text

, , +14

Two levels of protection for the B cell genome during somatic hypermutation

Man Liu, Jamie L. Duke, Daniel J. Richter et al. · Nature · 2008 · 565 citations

, , +8

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Florian Klein, Ron Diskin, Johannes F. Scheid et al. · Cell · 2013 · 564 citations · Full text

, , +16

Low-fidelity DNA synthesis by human DNA polymerase theta

Mercedes E. Arana, Mineaki Seki, Richard D. Wood et al. · Nucleic Acids Research · 2008 · 154 citations · Full text

, , +17

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

Youri I. Pavlov, Igor B. Rogozin, Anna Y. Aksenova et al. · Proceedings of the National Academy of Sciences · 2002 · 119 citations

, , +15

1–5 of 16

Authors

151

  1. IB
    Igor B. Rogozin

    National Center for Biotechnology Information, United States

    2 publications · 273 citations

    2

    h-index

  2. TA
    Thomas A. Kunkel

    National Institute of Environmental Health Sciences, United States

    2 publications · 273 citations

    2

    h-index

  3. IS
    Ivelin S. Georgiev

    National Institutes of Health, United States

    2 publications · 660 citations

    2

    h-index

  4. PD
    Peter D. Kwong

    National Institutes of Health, United States

    2 publications · 660 citations

    2

    h-index

  5. ZF
    Zachary F. Pursell

    Tulane University, United States

    1 publications · 796 citations

    1

    h-index

1–5 of 151

Institutions

77

  1. National Institutes of Health

    Bethesda, United States

    4 h-index

    33 publications

    4.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    4 publications

    1.7K citations

  3. Universität Hamburg

    Hamburg, Germany

    2 h-index

    2 publications

    1.4K citations

  4. National Institute of Environmental Health Sciences

    Durham, United States

    2 h-index

    7 publications

    772 citations

  5. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    2 h-index

    18 publications

    3.6K citations

  6. University Medical Center Hamburg-Eppendorf

    Hamburg, Germany

    2 h-index

    2 publications

    1.4K citations

  7. Institute of Molecular and Clinical Ophthalmology Basel

    Basel, Switzerland

    1 h-index

    1 publications

    11 citations

  8. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    1 publications

    564 citations

1–8 of 77

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 221 citations

    3

    h-index

  2. Cell

    2 publications · 1.4K citations

    2

    h-index

  3. Nucleic Acids Research

    2 publications · 257 citations

    2

    h-index

  4. Journal of Molecular Evolution

    1 publications · 40 citations

    1

    h-index

  5. Current topics in microbiology and immunology

    Book series · 1 publications · 11 citations

    1

    h-index

1–5