Concepedia

Somatic Hypermutation Engineering

Somatic Hypermutation Engineering is a methodological framework in antibody specificity engineering that artificially modulates the somatic hypermutation process to direct the in vitro evolution of antibodies with enhanced affinity and specificity.

23

Publications

2.2K

Citations

127

Authors

56

Institutions

Publications per year

2017–2026

7

Parents

Publications

23

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

Gaelen T. Hess, Laure Frésard, Kyuho Han et al. · Nature Methods · 2016 · 483 citations · Full text

, , +7

Evolution of new nonantibody proteins via iterative somatic hypermutation

Lei Wang, W. Coyt Jackson, Paul Steinbach et al. · Proceedings of the National Academy of Sciences · 2004 · 415 citations · Full text

, , +15

Improving antibody affinity by mimicking somatic hypermutation in vitro

Partha S. Chowdhury, Ira Pastan · Nature Biotechnology · 1999 · 259 citations

, , +14

Mimicking Somatic Hypermutation: Affinity Maturation of Antibodies Displayed on Bacteriophage Using a Bacterial Mutator Strain

Nigel M. Low, Philipp Holliger, Greg Winter · Journal of Molecular Biology · 1996 · 217 citations

, , +16

Rapid generation of potent antibodies by autonomous hypermutation in yeast

Alon Wellner, Conor McMahon, Morgan S. A. Gilman et al. · Nature Chemical Biology · 2021 · 134 citations · Full text

, , +17

1–5 of 23

Authors

127

  1. MV
    Mariia V. Guryleva

    Karolinska Institutet, Sweden

    2 publications · 106 citations

    2

    h-index

  2. TM
    Timothy M. Caradonna

    Ragon Institute of MGH, MIT and Harvard, United States

    2 publications · 160 citations

    2

    h-index

  3. DN
    David Nemazee

    Scripps Research Institute, United States

    2 publications · 106 citations

    2

    h-index

  4. AC
    Andrew C. Kruse

    Harvard University, United States

    2 publications · 160 citations

    2

    h-index

  5. LM
    Laura M. Wingler

    Duke Medical Center, United States

    2 publications · 160 citations

    2

    h-index

1–5 of 127

Institutions

56

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    7 publications

    1.9K citations

  2. Ragon Institute of MGH, MIT and Harvard

    Cambridge, United States

    4 h-index

    12 publications

    852 citations

  3. University of California San Diego

    San Diego, United States

    3 h-index

    13 publications

    755 citations

  4. Scripps Research Institute

    San Diego, United States

    3 h-index

    38 publications

    1.8K citations

  5. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    3 h-index

    6 publications

    1.2K citations

  6. University of California, Irvine

    Irvine, United States

    2 h-index

    11 publications

    934 citations

  7. Harvard University

    Cambridge, United States

    2 h-index

    16 publications

    1.3K citations

  8. Universidad Autónoma de Madrid

    Madrid, Spain

    2 h-index

    2 publications

    106 citations

1–8 of 56

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 530 citations

    3

    h-index

  2. The Journal of Immunology

    JI · 2 publications · 39 citations

    2

    h-index

  3. Protein Engineering Design and Selection

    PEDS · 2 publications · 65 citations

    2

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 50 citations

    2

    h-index

  5. mAbs

    1 publications · 59 citations

    1

    h-index

1–5