Concepedia

Solid-phase Dna Synthesis

Solid-Phase DNA Synthesis is a chemical method for artificially constructing DNA molecules in which nucleotides are sequentially added to a growing oligonucleotide chain covalently bound to an insoluble solid support, enabling stepwise synthesis through cycles of deprotection, coupling, and washing.

273

Publications

11.2K

Citations

784

Authors

237

Institutions

Publications per year

2017–2026

14

Parents

Publications

273

Gene Synthesis Machines: DNA Chemistry and Its Uses

Marvin H. Caruthers · Science · 1985 · 791 citations

, , +15

Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids

Eldon E. Baird, Peter B. Dervan · Journal of the American Chemical Society · 1996 · 359 citations

, , +12

IN VITRO MUTAGENESIS

Michael D. Smith · Annual Review of Genetics · 1985 · 340 citations

, , +17

Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis

Bernhard Virnekäs, Liming Ge, Andreas Plu€kthun et al. · Nucleic Acids Research · 1994 · 233 citations · Full text

, , +17

Solid phase synthesis of polynucleotides. VI. Farther studies on polystyrene copolymers for the solid support

Hirataka Ito, Yoshimasa Ike, Satoshi Ikuta et al. · Nucleic Acids Research · 1982 · 219 citations · Full text

, , +15

1–5 of 273

Authors

784

  1. JH
    Jacques H. van Boom

    Leiden University, Netherlands

    11 publications · 408 citations

    10

    h-index

  2. MW
    Mark W. Grinstaff

    Boston University, United States

    7 publications · 216 citations

    7

    h-index

  3. LD
    Lorenzo De Napoli

    University of Naples Federico II, Italy

    7 publications · 174 citations

    7

    h-index

  4. TC
    Thomas C. Bruice

    University of California, Santa Barbara, United States

    7 publications · 172 citations

    7

    h-index

  5. MJ
    Michael J. Gait

    MRC Laboratory of Molecular Biology, United Kingdom

    5 publications · 307 citations

    6

    h-index

1–5 of 784

Institutions

237

  1. University of California, Santa Barbara

    Santa Barbara, United States

    8 h-index

    16 publications

    445 citations

  2. University of Naples Federico II

    Naples, Italy

    8 h-index

    38 publications

    956 citations

  3. Duke University

    Durham, United States

    8 h-index

    31 publications

    963 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    28 publications

    1.2K citations

  5. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    7 h-index

    14 publications

    1K citations

  6. Centre de Biophysique Moléculaire

    Orléans, France

    6 h-index

    19 publications

    807 citations

  7. City of Hope

    Lancaster, United States

    6 h-index

    25 publications

    2.2K citations

  8. TU Dortmund University

    Dortmund, Germany

    6 h-index

    17 publications

    397 citations

1–8 of 237

Venues

  1. Nucleic Acids Research

    41 publications · 2.4K citations

    31

    h-index

  2. Tetrahedron Letters

    45 publications · 1.4K citations

    26

    h-index

  3. Journal of the American Chemical Society

    JACS · 13 publications · 1.3K citations

    13

    h-index

  4. The Journal of Organic Chemistry

    JOC · 13 publications · 380 citations

    13

    h-index

  5. Tetrahedron

    10 publications · 293 citations

    10

    h-index

1–5