Concepedia

Small-molecule Probing

Small-Molecule Probing is a targeted experimental methodology in reverse chemical genetics that employs bioactive small molecules to selectively modulate protein function, thereby enabling the systematic interrogation of gene-protein-phenotype relationships in biological systems.

43

Publications

3K

Citations

275

Authors

111

Institutions

Publications per year

2017–2026

16

Parents

Publications

43

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

Robert L. Strausberg, Stuart L. Schreiber · Science · 2003 · 259 citations

, , +16

Transglutaminase-Catalyzed Site-Specific Conjugation of Small-Molecule Probes to Proteins in Vitro and on the Surface of Living Cells

Chi‐Wang Lin, Alice Y. Ting · Journal of the American Chemical Society · 2006 · 234 citations · Full text

, , +14

An integrated platform of genomic assays reveals small-molecule bioactivities

Shawn Hoon, Andrew Smith, Iain M. Wallace et al. · Nature Chemical Biology · 2008 · 207 citations

, , +13

Genome-wide determination of drug localization

Lars Anders, Matthew G. Guenther, Jun Qi et al. · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · 2014 · 182 citations · Full text

, , +4

Ligand‐Directed Selective Protein Modification Based on Local Single‐Electron‐Transfer Catalysis

Shinichi Sato, Hiroyuki Nakamura · Angewandte Chemie International Edition · 2013 · 176 citations · Full text

, , +15

1–5 of 43

Authors

275

  1. SL
    Stuart L. Schreiber

    Harvard University, United States

    3 publications · 411 citations

    3

    h-index

  2. SS
    Shinichi Sato

    Tokyo Institute of Technology, Japan

    2 publications · 211 citations

    2

    h-index

  3. PW
    Paul Workman

    Institute of Cancer Research, United Kingdom

    2 publications · 69 citations

    2

    h-index

  4. HN
    Hiroyuki Nakamura

    Tokyo Institute of Technology, Japan

    2 publications · 211 citations

    2

    h-index

  5. AS
    Alanna Schepartz

    Yale University, United States

    1 publications · 68 citations

    1

    h-index

1–5 of 275

Institutions

111

  1. University of Toronto

    Toronto, Canada

    3 h-index

    9 publications

    1.3K citations

  2. Institute of Cancer Research

    London, United Kingdom

    3 h-index

    10 publications

    558 citations

  3. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    4 publications

    288 citations

  4. University at Albany, State University of New York

    Albany, United States

    2 h-index

    5 publications

    390 citations

  5. Goethe University Frankfurt

    Frankfurt am Main, Germany

    2 h-index

    6 publications

    575 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    3 publications

    457 citations

  7. University of Tübingen

    Tübingen, Germany

    2 h-index

    9 publications

    264 citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    3 publications

    650 citations

1–8 of 111

Venues

  1. Nature Chemical Biology

    4 publications · 394 citations

    4

    h-index

  2. Journal of Medicinal Chemistry

    3 publications · 158 citations

    3

    h-index

  3. Journal of the American Chemical Society

    JACS · 3 publications · 314 citations

    3

    h-index

  4. Analytical Chemistry

    2 publications · 155 citations

    2

    h-index

  5. Chemical Communications

    ChemComm · 2 publications · 136 citations

    2

    h-index

1–5