Concepedia

Smad1 Activation

Smad1 Activation is a molecular signaling event within the transforming growth factor-beta pathway that specifically denotes the phosphorylation-induced transition of the Smad1 protein from an inactive to an active state, enabling its role in transcriptional regulation of target genes involved in osteogenic and developmental processes.

368

Publications

25.2K

Citations

2.3K

Authors

671

Institutions

Publications per year

2017–2026

103

Parents

Publications

368

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

Marcus Kretzschmar, Jacqueline Doody, Joan Massagu� · Nature · 1997 · 871 citations

, , +9

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

Akiko Hata, Giorgio Lagna, Joan Massagué et al. · Genes & Development · 1998 · 722 citations · Full text

, , +12

Crystal Structure of a Smad MH1 Domain Bound to DNA

Yigong Shi, Yanfei Wang, Lata Jayaraman et al. · Cell · 1998 · 718 citations · Full text

, , +14

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

Marcus Kretzschmar, F Liu, Akiko Hata et al. · Genes & Development · 1997 · 572 citations · Full text

, , +13

SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes

Kristin Verschueren, Jacques Remacle, Clara Collart et al. · Journal of Biological Chemistry · 1999 · 504 citations · Full text

, , +14

1–5 of 368

Authors

2.3K

  1. HA
    Hideharu Abe

    Tokushima University, Japan

    9 publications · 404 citations

    9

    h-index

  2. KN
    Kojiro Nagai

    Tokushima University, Japan

    8 publications · 393 citations

    8

    h-index

  3. TD
    Toshio Doi

    Tokushima University, Japan

    8 publications · 393 citations

    8

    h-index

  4. TM
    Takeshi Matsubara

    Kyoto University, Japan

    7 publications · 379 citations

    7

    h-index

  5. PT
    Peter ten Dijke

    Leiden University Medical Center, Netherlands

    7 publications · 695 citations

    7

    h-index

1–5 of 2.3K

Institutions

671

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    24 publications

    10.5K citations

  2. Tokushima University

    Tokushima, Japan

    10 h-index

    58 publications

    2.1K citations

  3. Shanghai Jiao Tong University

    Shanghai, China

    8 h-index

    60 publications

    1.9K citations

  4. Sun Yat-sen University

    Guangzhou, China

    8 h-index

    55 publications

    5.1K citations

  5. Inserm

    Paris, France

    8 h-index

    34 publications

    2.5K citations

  6. Central South University

    Changsha, China

    8 h-index

    40 publications

    2K citations

  7. National Institutes of Health

    Bethesda, United States

    7 h-index

    13 publications

    966 citations

  8. Memorial Sloan Kettering Cancer Center

    New York, United States

    7 h-index

    21 publications

    11.8K citations

1–8 of 671

Venues

  1. Journal of Biological Chemistry

    JBC · 33 publications · 4.3K citations

    29

    h-index

  2. PLoS ONE

    17 publications · 989 citations

    16

    h-index

  3. PubMed

    Repository · 10 publications · 328 citations

    10

    h-index

  4. Journal of Cellular Physiology

    9 publications · 386 citations

    9

    h-index

  5. Journal of Bone and Mineral Research

    JBMR · 8 publications · 862 citations

    8

    h-index

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