Concepedia

Smac Release

Smac Release is a molecular event in the intrinsic apoptosis pathway wherein the mitochondrial protein Smac/DIABLO is released into the cytosol to neutralize inhibitor of apoptosis proteins (IAPs), thereby promoting caspase activation and apoptosome-mediated cell death.

86

Publications

6.9K

Citations

526

Authors

176

Institutions

Publications per year

2017–2026

11

Parents

Publications

86

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

Yin Guo, Srinivasa M. Srinivasula, Anne Druilhe et al. · Journal of Biological Chemistry · 2002 · 517 citations · Full text

, , +17

Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2

Colin Adrain · The EMBO Journal · 2001 · 436 citations · Full text

, , +14

Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro

Marion MacFarlane, Wendy Merrison, Shawn B. Bratton et al. · Journal of Biological Chemistry · 2002 · 296 citations · Full text

, , +17

Overexpression of Copper/Zinc Superoxide Dismutase in Transgenic Rats Protects Vulnerable Neurons against Ischemic Damage by Blocking the Mitochondrial Pathway of Caspase Activation

Taku Sugawara, Nobuo Noshita, Anders Lewén et al. · Journal of Neuroscience · 2002 · 267 citations · Full text

, , +17

Akt-Mediated Cisplatin Resistance in Ovarian Cancer: Modulation of p53 Action on Caspase-Dependent Mitochondrial Death Pathway

Xiaokui Yang, Michael Fraser, Ute M. Moll et al. · Cancer Research · 2006 · 247 citations

, , +17

1–5 of 86

Authors

526

  1. SG
    Steven Grant

    Virginia Commonwealth University, United States

    4 publications · 157 citations

    4

    h-index

  2. ES
    Emad S. Alnemri

    Thomas Jefferson University, United States

    3 publications · 896 citations

    3

    h-index

  3. CD
    Chunying Du

    Stowers Institute for Medical Research, United States

    3 publications · 345 citations

    3

    h-index

  4. SM
    Srinivasa M. Srinivasula

    Thomas Jefferson University, United States

    3 publications · 896 citations

    3

    h-index

  5. MR
    Markus Rehm

    Ludwig-Maximilians-Universität München, Germany

    3 publications · 235 citations

    3

    h-index

1–5 of 526

Institutions

176

  1. Virginia Commonwealth University Medical Center

    Richmond, United States

    4 h-index

    8 publications

    287 citations

  2. Sidney Kimmel Cancer Center

    Philadelphia, United States

    3 h-index

    11 publications

    3K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    16 publications

    2.8K citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    15 publications

    2.6K citations

  5. Central South University

    Changsha, China

    3 h-index

    12 publications

    709 citations

  6. University of Manitoba

    Winnipeg, Canada

    2 h-index

    8 publications

    635 citations

  7. Monash University

    Melbourne, Australia

    2 h-index

    4 publications

    187 citations

  8. Vanderbilt University

    Nashville, United States

    2 h-index

    2 publications

    149 citations

1–8 of 176

Venues

  1. Journal of Biological Chemistry

    JBC · 13 publications · 2K citations

    12

    h-index

  2. PubMed

    Repository · 7 publications · 576 citations

    7

    h-index

  3. Cell Death and Disease

    4 publications · 189 citations

    4

    h-index

  4. Cell Death and Differentiation

    CDD · 4 publications · 108 citations

    4

    h-index

  5. Oncogene

    4 publications · 392 citations

    4

    h-index

1–5