Concepedia

Single-nucleus Epigenomics

Single-Nucleus Epigenomics is a methodological framework within epigenomics that enables the genome-wide profiling of chromatin states and regulatory elements at the resolution of individual nuclei, distinguished from bulk or cell-based approaches by its application to isolated nuclei, thereby facilitating the study of epigenetic heterogeneity in complex tissues with minimal dissociation artifacts.

42

Publications

5.6K

Citations

604

Authors

173

Institutions

Publications per year

2017–2026

41

Parents

Publications

42

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

Hongjie Li, Jasper Janssens, Maxime De Waegeneer et al. · Science · 2022 · 848 citations · Full text

, , +14

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease

Samuel Morabito, Emily Miyoshi, Neethu Michael et al. · Nature Genetics · 2021 · 706 citations · Full text

, , +16

Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex

Chongyuan Luo, Christopher L. Keown, Laurie Kurihara et al. · Science · 2017 · 611 citations

, , +17

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Mark Chaffin, Irinna Papangeli, Bridget Simonson et al. · Nature · 2022 · 392 citations

, , +13

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

Rongxin Fang, Hui Huang, Yuan Zhao et al. · Nature Neuroscience · 2018 · 389 citations · Full text

, , +14

1–5 of 42

Authors

604

  1. JR
    Joseph R. Nery

    Salk Institute for Biological Studies, United States

    12 publications · 1.5K citations

    12

    h-index

  2. JR
    Joseph R. Ecker

    Salk Institute for Biological Studies, United States

    13 publications · 1.6K citations

    12

    h-index

  3. AB
    Anna Bartlett

    Salk Institute for Biological Studies, United States

    11 publications · 937 citations

    11

    h-index

  4. RC
    Rosa Castanon

    Salk Institute for Biological Studies, United States

    11 publications · 1.5K citations

    11

    h-index

  5. HL
    Hanqing Liu

    Salk Institute for Biological Studies, United States

    11 publications · 937 citations

    11

    h-index

1–5 of 604

Institutions

173

  1. University of California San Diego

    San Diego, United States

    15 h-index

    102 publications

    15.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    53 publications

    22.4K citations

  3. Salk Institute for Biological Studies

    La Jolla, United States

    12 h-index

    230 publications

    25.8K citations

  4. University of California, Los Angeles

    Los Angeles, United States

    8 h-index

    15 publications

    844 citations

  5. Ludwig Cancer Research

    New York, United States

    7 h-index

    24 publications

    5.1K citations

  6. Stanford University

    Stanford, United States

    5 h-index

    53 publications

    34.9K citations

  7. Allen Institute

    Seattle, United States

    4 h-index

    14 publications

    1.2K citations

  8. Allen Institute for Brain Science

    Seattle, United States

    4 h-index

    14 publications

    1.2K citations

1–8 of 173

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 6 publications · 133 citations

    6

    h-index

  2. Nature

    4 publications · 904 citations

    4

    h-index

  3. Nature Protocols

    3 publications · 168 citations

    3

    h-index

  4. Neuron

    2 publications · 298 citations

    2

    h-index

  5. Cell Reports

    2 publications · 91 citations

    2

    h-index

1–5