Concepedia

Single-nucleus Differential Expression

Single-Nucleus Differential Expression is a computational analysis framework that identifies statistically significant changes in gene expression levels across individual nuclei derived from single-nucleus RNA sequencing data, distinguishing it from bulk or single-cell approaches by enabling resolution of transcriptional heterogeneity in tissues with low cellular integrity or accessibility.

26

Publications

3.1K

Citations

307

Authors

100

Institutions

Publications per year

2017–2026

25

Parents

Publications

26

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey et al. · Nature Medicine · 2020 · 1.2K citations · Full text

, , +16

Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

Michael J. Petrany, Casey O. Swoboda, Chengyi Sun et al. · Nature Communications · 2020 · 402 citations · Full text

, , +15

Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

Miao Cui, Zhaoning Wang, Kenian Chen et al. · Developmental Cell · 2020 · 176 citations · Full text

, , +16

Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk

Adam W. Turner, Shengen Shawn Hu, José Verdezoto Mosquera et al. · Nature Genetics · 2022 · 157 citations · Full text

, , +16

Nuclei and subnuclei gene expression profiling in mammalian brain

Pascal Bonaventure, Hongqing Guo, Bin Tian et al. · Brain Research · 2002 · 154 citations

, , +14

1–5 of 26

Authors

307

  1. XC
    Xiaoting Chen

    Cincinnati Children's Hospital Medical Center, United States

    2 publications · 433 citations

    2

    h-index

  2. MJ
    Michael J. Petrany

    Cincinnati Children's Hospital Medical Center, United States

    2 publications · 433 citations

    2

    h-index

  3. DP
    Douglas P. Millay

    Cincinnati Children's Hospital Medical Center, United States

    2 publications · 433 citations

    2

    h-index

  4. NS
    Nathan Salomonis

    Cincinnati Children's Hospital Medical Center, United States

    2 publications · 433 citations

    2

    h-index

  5. MT
    Matthew T. Weirauch

    Cincinnati Children's Hospital Medical Center, United States

    2 publications · 433 citations

    2

    h-index

1–5 of 307

Institutions

100

  1. University of Cincinnati Medical Center

    Cincinnati, United States

    3 h-index

    9 publications

    1.4K citations

  2. Icahn School of Medicine at Mount Sinai

    New York, United States

    3 h-index

    13 publications

    1.1K citations

  3. Cincinnati Children's Hospital Medical Center

    Cincinnati, United States

    3 h-index

    17 publications

    3.5K citations

  4. Stanford University

    Stanford, United States

    3 h-index

    15 publications

    1.8K citations

  5. Hope Center for Neurological Disorders

    St Louis, United States

    2 h-index

    17 publications

    3.8K citations

  6. Washington University in St. Louis

    St Louis, United States

    2 h-index

    27 publications

    12.5K citations

  7. University of California San Diego

    San Diego, United States

    2 h-index

    17 publications

    629 citations

  8. University of Alabama at Birmingham

    Birmingham, United States

    2 h-index

    2 publications

    112 citations

1–8 of 100

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 4 publications · 91 citations

    4

    h-index

  2. Nature Communications

    3 publications · 620 citations

    3

    h-index

  3. Nature Medicine

    2 publications · 1.2K citations

    2

    h-index

  4. Nature Neuroscience

    1 publications · 32 citations

    1

    h-index

  5. Nature Protocols

    1 publications · 49 citations

    1

    h-index

1–5