Concepedia

Siglec Interactions

Siglec Interactions is a glycan-protein interaction characterized by the specific binding of sialic acid-binding immunoglobulin-type lectins (Siglecs) to sialylated glycans, mediating cell-cell recognition, immune regulation, and signal transduction in the context of glycoimmunology.

125

Publications

10.2K

Citations

846

Authors

290

Institutions

Publications per year

2017–2026

44

Parents

Publications

125

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Jun Wang, Jingwei Sun, Linda N. Liu et al. · Nature Medicine · 2019 · 697 citations · Full text

, , +14

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

Jason E. Hudak, Stephen M. Canham, Carolyn R. Bertozzi · Nature Chemical Biology · 2013 · 495 citations · Full text

, , +16

Glycan Array Screening Reveals a Candidate Ligand for Siglec-8*

Bruce S. Bochner, Richard Alvarez, Padmaja Mehta et al. · Journal of Biological Chemistry · 2004 · 262 citations · Full text

, , +17

Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12

Amanda L. Blasius, Marina Cella, Jorge Maldonado‐Mahauad et al. · Blood · 2005 · 251 citations · Full text

, , +8

Sialoside Specificity of the Siglec Family Assessed Using Novel Multivalent Probes

Ola Blixt, Brian E. Collins, Ingrid M. van den Nieuwenhof et al. · Journal of Biological Chemistry · 2003 · 246 citations · Full text

, , +17

1–5 of 125

Authors

846

  1. PR
    Paul R. Crocker

    University of Dundee, United Kingdom

    22 publications · 2.1K citations

    21

    h-index

  2. AV
    Ajit Varki

    University of California San Diego, United States

    10 publications · 1.2K citations

    10

    h-index

  3. JC
    James C. Paulson

    Scripps Research Institute, United States

    7 publications · 918 citations

    8

    h-index

  4. MS
    Matthew S. Macauley

    University of Alberta, Canada

    6 publications · 266 citations

    6

    h-index

  5. TA
    Takashi Angata

    Institute of Biological Chemistry, Academia Sinica, Taiwan

    6 publications · 578 citations

    6

    h-index

1–5 of 846

Institutions

290

  1. University of Dundee

    Dundee, United Kingdom

    21 h-index

    37 publications

    3.9K citations

  2. Wellcome Trust

    London, United Kingdom

    14 h-index

    25 publications

    3K citations

  3. University of California San Diego

    San Diego, United States

    12 h-index

    42 publications

    4.2K citations

  4. Scripps Research Institute

    San Diego, United States

    11 h-index

    44 publications

    5.8K citations

  5. Johns Hopkins University

    Baltimore, United States

    9 h-index

    24 publications

    2.4K citations

  6. University of Alberta

    Edmonton, Canada

    7 h-index

    51 publications

    2.6K citations

  7. Johns Hopkins Medicine

    Baltimore, United States

    7 h-index

    17 publications

    1.8K citations

  8. University of Montana

    Missoula, United States

    5 h-index

    15 publications

    1.9K citations

1–8 of 290

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 1.4K citations

    14

    h-index

  2. Glycobiology

    7 publications · 531 citations

    7

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 694 citations

    5

    h-index

  4. Journal of Allergy and Clinical Immunology

    4 publications · 385 citations

    4

    h-index

  5. Frontiers in Immunology

    4 publications · 131 citations

    4

    h-index

1–5