Concepedia

Sh3-binding Motif

An SH3-Binding Motif is a short peptide sequence motif that serves as a molecular recognition element selectively interacting with the Src Homology 3 (SH3) domain of signaling proteins to mediate protein-protein interactions in cellular pathways.

707

Publications

64.5K

Citations

3.2K

Authors

848

Institutions

Publications per year

2017–2026

38

Variants

Sh3-binding MotifsSh3-binding Peptide MotifSh3-binding Peptide Motifs

Parents

Publications

707

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

Ruibao Ren, Bruce J. Mayer, Piera Cicchetti et al. · Science · 1993 · 1.2K citations

, , +16

Structural basis for the binding of proline-rich peptides to SH3 domains

Hongtao Yu, James Chen, Sibo Feng et al. · Cell · 1994 · 1K citations

, , +15

GlobPlot: exploring protein sequences for globularity and disorder

Rune Linding · Nucleic Acids Research · 2003 · 1K citations · Full text

, , +17

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

Wenqing Xu, Amish Doshi, Ming Lei et al. · Molecular Cell · 1999 · 874 citations · Full text

, , +16

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

Scott G. Clark, Michael Stern, H. Robert Horvritz · Nature · 1992 · 602 citations

, , +10

1–5 of 707

Authors

3.2K

  1. KS
    Kalle Saksela

    University of Helsinki, Finland

    24 publications · 2.2K citations

    20

    h-index

  2. TE
    Thomas E. Smithgall

    University of Pittsburgh, United States

    14 publications · 741 citations

    13

    h-index

  3. SM
    Stephan M. Feller

    University of Oxford, United Kingdom

    13 publications · 897 citations

    13

    h-index

  4. BJ
    Bruce J. Mayer

    UConn Health, United States

    11 publications · 2.4K citations

    11

    h-index

  5. HH
    Hidesaburô Hanafusa

    Rockefeller University, United States

    9 publications · 923 citations

    9

    h-index

1–5 of 3.2K

Institutions

848

  1. Harvard University

    Cambridge, United States

    31 h-index

    116 publications

    20.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    31 h-index

    89 publications

    17.2K citations

  3. Rockefeller University

    New York, United States

    26 h-index

    103 publications

    24K citations

  4. University of Toronto

    Toronto, Canada

    21 h-index

    88 publications

    7.3K citations

  5. Inserm

    Paris, France

    20 h-index

    117 publications

    7.2K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    20 h-index

    130 publications

    5.8K citations

  7. University of Helsinki

    Helsinki, Finland

    19 h-index

    51 publications

    2.4K citations

  8. The University of Tokyo

    Tokyo, Japan

    18 h-index

    44 publications

    4.6K citations

1–8 of 848

Venues

  1. Journal of Biological Chemistry

    JBC · 139 publications · 13.8K citations

    73

    h-index

  2. Molecular and Cellular Biology

    MCB · 28 publications · 3.2K citations

    27

    h-index

  3. Journal of Molecular Biology

    JMB · 33 publications · 2K citations

    26

    h-index

  4. The EMBO Journal

    25 publications · 4.4K citations

    25

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 3.9K citations

    21

    h-index

1–5