Concepedia

Sequence-function Landscapes

Sequence-Function Landscapes is a theoretical framework that maps the relationship between biological sequence variation and functional phenotypes by representing sequences as points in a high-dimensional space where each dimension corresponds to a functional trait, thereby enabling the analysis of evolutionary trajectories under selective pressures.

20

Publications

1.8K

Citations

74

Authors

32

Institutions

Publications per year

2017–2026

12

Parents

Publications

20

Expanding functional protein sequence spaces using generative adversarial networks

Donatas Repecka, Vykintas Jauniškis, Laurynas Karpus et al. · Nature Machine Intelligence · 2021 · 379 citations

, , +12

Scaling laws in the functional content of genomes

Erik van Nimwegen · Trends in Genetics · 2003 · 319 citations

, , +9

Comprehensive experimental fitness landscape and evolutionary network for small RNA

José I. Jiménez, Ramón Xulvi-Brunet, Gregory W. Campbell et al. · Proceedings of the National Academy of Sciences · 2013 · 156 citations · Full text

, , +17

Multiplexed gene synthesis in emulsions for exploring protein functional landscapes

Calin Plesa, Angus M. Sidore, Nathan B. Lubock et al. · Science · 2018 · 150 citations · Full text

, , +15

Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations

Neil Peterman, Erel Levine · BMC Genomics · 2016 · 124 citations · Full text

, , +13

1–5 of 20

Authors

74

  1. FH
    Frances H. Arnold

    California Institute of Technology, United States

    1 publications · 63 citations

    2

    h-index

  2. AM
    Angus M. Sidore

    University of California, Los Angeles, United States

    1 publications · 150 citations

    1

    h-index

  3. JI
    José I. Jiménez

    University of Surrey, United Kingdom

    1 publications · 156 citations

    1

    h-index

  4. KY
    Kevin Yang

    Microsoft (United States), United States

    1 publications · 63 citations

    1

    h-index

  5. SS
    Sam Sinai

    Harvard University, United States

    1 publications · 16 citations

    1

    h-index

1–5 of 74

Institutions

32

  1. Center for Systems Biology

    Boston, United States

    2 h-index

    6 publications

    872 citations

  2. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    2 publications

    269 citations

  3. Harvard University

    Cambridge, United States

    2 h-index

    6 publications

    872 citations

  4. California Institute of Technology

    Pasadena, United States

    2 h-index

    6 publications

    378 citations

  5. University of Manchester

    Manchester, United Kingdom

    1 h-index

    1 publications

    59 citations

  6. University of California, Santa Barbara

    Santa Barbara, United States

    1 h-index

    2 publications

    312 citations

  7. Vrije Universiteit Brussel

    Brussels, Belgium

    1 h-index

    2 publications

    84 citations

  8. Vilnius University

    Vilnius, Lithuania

    1 h-index

    3 publications

    1.1K citations

1–8 of 32

Venues

  1. Nature Communications

    4 publications · 159 citations

    4

    h-index

  2. Science

    2 publications · 209 citations

    2

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 219 citations

    2

    h-index

  4. arXiv (Cornell University)

    Repository · 1 publications · 16 citations

    1

    h-index

  5. Antimicrobial Agents and Chemotherapy

    AAC · 1 publications · 25 citations

    1

    h-index

1–5