Concepedia

Evolutionary Trajectory Analysis

Evolutionary Trajectory Analysis is a computational and experimental methodology within directed evolution that identifies, characterizes, and interprets the sequential mutational pathways and selective pressures guiding the optimization of biomolecular function over successive generations.

250

Publications

16.6K

Citations

2.2K

Authors

802

Institutions

Publications per year

2017–2026

95

Parents

Children

Publications

250

Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

Daniel Weinreich, Nigel F. Delaney, Mark A. DePristo et al. · Science · 2006 · 1.5K citations

, , +17

The dynamics of molecular evolution over 60,000 generations

Benjamin H. Good, Michael J. McDonald, Jeffrey E. Barrick et al. · Nature · 2017 · 844 citations · Full text

, , +10

Global epistasis makes adaptation predictable despite sequence-level stochasticity

Sergey Kryazhimskiy, Daniel P. Rice, Elizabeth R. Jerison et al. · Science · 2014 · 548 citations

, , +17

The Lévy flight paradigm: random search patterns and mechanisms

Andy M. Reynolds, Christopher J. Rhodes · Ecology · 2009 · 312 citations

, , +13

Modeling evolutionary landscapes: Mutational stability, topology, and superfunnels in sequence space

Erich Bornberg‐Bauer, Hue Sun Chan · Proceedings of the National Academy of Sciences · 1999 · 265 citations

, , +15

1–5 of 250

Authors

2.2K

  1. MM
    Michael M. Desai

    Harvard University, United States

    6 publications · 1.6K citations

    6

    h-index

  2. RE
    Richard E. Lenski

    Michigan State University, United States

    4 publications · 1.2K citations

    4

    h-index

  3. AH
    Allan Haldane

    Temple University, United States

    3 publications · 80 citations

    3

    h-index

  4. DL
    Daniel L. Hartl

    Harvard University, United States

    3 publications · 1.6K citations

    3

    h-index

  5. GC
    Giulio Caravagna

    Institute of Cancer Research, United Kingdom

    3 publications · 150 citations

    3

    h-index

1–5 of 2.2K

Institutions

802

  1. Harvard University

    Cambridge, United States

    20 h-index

    88 publications

    15.1K citations

  2. University of Washington

    Seattle, United States

    9 h-index

    23 publications

    1.8K citations

  3. Michigan State University

    East Lansing, United States

    8 h-index

    58 publications

    5.9K citations

  4. Stanford University

    Stanford, United States

    8 h-index

    22 publications

    1.1K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    26 publications

    885 citations

  6. Uppsala University

    Uppsala, Sweden

    8 h-index

    24 publications

    1.2K citations

  7. Center for Systems Biology

    Boston, United States

    7 h-index

    16 publications

    5.4K citations

  8. Pennsylvania State University

    State College, United States

    6 h-index

    14 publications

    570 citations

1–8 of 802

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.3K citations

    17

    h-index

  2. Molecular Biology and Evolution

    MBE · 16 publications · 959 citations

    15

    h-index

  3. Nature Communications

    12 publications · 719 citations

    12

    h-index

  4. eLife

    11 publications · 531 citations

    11

    h-index

  5. Journal of Molecular Evolution

    10 publications · 396 citations

    10

    h-index

1–5