Concepedia

Self-tolerance Breakdown

Self-Tolerance Breakdown is a pathological immunological phenomenon in which the immune system fails to recognize self-antigens as non-threatening, leading to the activation of autoreactive lymphocytes that mediate tissue damage characteristic of autoimmune hypersensitivity disorders.

108

Publications

8.9K

Citations

502

Authors

213

Institutions

Publications per year

2017–2026

16

Variants

Loss Of Self-tolerance

Parents

Publications

108

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

Shelley Lindley, Colin Dayan, Amanda J. Bishop et al. · Diabetes · 2005 · 854 citations · Full text

, , +17

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

Émilie Mamessier, Aude Sylvain, Marie‐Laure Thibult et al. · Journal of Clinical Investigation · 2011 · 676 citations · Full text

, , +17

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4<sup>+</sup> T cells

Benjamin Sadlack, Jürgen Löhler, Hubert Schorle et al. · European Journal of Immunology · 1995 · 423 citations

, , +17

CD4+ Tregs and immune control

Zoltán Fehérvári, Shimon Sakaguchi · Journal of Clinical Investigation · 2004 · 349 citations

, , +17

Breakdown of self-tolerance in anergic B lymphocytes

Christopher C. Goodnow, Robert Brink, Elizabeth M. Adams · Nature · 1991 · 252 citations

, , +11

1–5 of 108

Authors

502

  1. SS
    Shimon Sakaguchi

    Kyoto University, Japan

    3 publications · 623 citations

    3

    h-index

  2. JM
    Jeremy M. Palmer

    Newcastle University, United Kingdom

    3 publications · 69 citations

    3

    h-index

  3. AC
    Anne Cooke

    University of Cambridge, United Kingdom

    2 publications · 105 citations

    2

    h-index

  4. UT
    Utano Tomaru

    Hokkaido University, Japan

    2 publications · 184 citations

    2

    h-index

  5. IR
    Irun R. Cohen

    Weizmann Institute of Science, Israel

    2 publications · 142 citations

    2

    h-index

1–5 of 502

Institutions

213

  1. Inserm

    Paris, France

    4 h-index

    19 publications

    2.1K citations

  2. National Cancer Institute

    Bethesda, United States

    4 h-index

    4 publications

    369 citations

  3. University of Naples Federico II

    Naples, Italy

    4 h-index

    5 publications

    265 citations

  4. Harvard University

    Cambridge, United States

    4 h-index

    11 publications

    645 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    7 publications

    870 citations

  6. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    7 publications

    525 citations

  7. University of Oxford

    Oxford, United Kingdom

    3 h-index

    9 publications

    482 citations

  8. Newcastle University

    Newcastle upon Tyne, United Kingdom

    3 h-index

    16 publications

    382 citations

1–8 of 213

Venues

  1. European Journal of Immunology

    EJI · 10 publications · 1.1K citations

    10

    h-index

  2. PubMed

    Repository · 9 publications · 406 citations

    9

    h-index

  3. The Journal of Immunology

    JI · 9 publications · 537 citations

    9

    h-index

  4. Journal of Clinical Investigation

    JCI · 9 publications · 1.8K citations

    9

    h-index

  5. The Journal of Experimental Medicine

    7 publications · 704 citations

    7

    h-index

1–5