Concepedia

Seeded Misfolding

Seeded Misfolding is a biochemical mechanism in which a misfolded prion protein acts as a template to induce the conformational conversion of normally folded prion proteins into the pathological isoform, thereby propagating protein aggregation in a self-perpetuating manner.

6

Publications

771

Citations

37

Authors

14

Institutions

Publications per year

2017–2026

3

Parents

Publications

6

Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae

John R. Glover, Anthony S. Kowal, Eric C. Schirmer et al. · Cell · 1997 · 599 citations · Full text

, , +13

Autocatalytic Conversion of Recombinant Prion Proteins Displays a Species Barrier

Ilia V. Baskakov · Journal of Biological Chemistry · 2004 · 88 citations · Full text

, , +16

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS

Emmanuel A. Asante, Jacqueline M. Linehan, Andrew Tomlinson et al. · PLoS Biology · 2020 · 25 citations · Full text

, , +17

Glycosaminoglycan Sulphation Affects the Seeded Misfolding of a Mutant Prion Protein

Victoria Lawson, Brooke Lumicisi, Jeremy Welton et al. · PLoS ONE · 2010 · 25 citations · Full text

, , +14

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Yo Ching Cheng, Samia Hannaoui, Theodore R. John et al. · Journal of Visualized Experiments · 2017 · 24 citations · Full text

, , +16

1–5 of 6

Authors

37

  1. YC
    Yo Ching Cheng

    University of Calgary, Canada

    2 publications · 34 citations

    2

    h-index

  2. SH
    Samia Hannaoui

    University of Calgary, Canada

    2 publications · 34 citations

    2

    h-index

  3. SD
    Sandor Dudas

    Canadian Food Inspection Agency, Canada

    2 publications · 34 citations

    2

    h-index

  4. SC
    Stefanie Czub

    Canadian Food Inspection Agency, Canada

    2 publications · 34 citations

    2

    h-index

  5. TR
    Theodore R. John

    University of Wyoming, United States

    2 publications · 34 citations

    2

    h-index

1–5 of 37

Institutions

14

  1. Canadian Food Inspection Agency

    Ottawa, Canada

    2 h-index

    4 publications

    68 citations

  2. University of Calgary

    Calgary, Canada

    2 h-index

    6 publications

    102 citations

  3. University of Wyoming

    Laramie, United States

    2 h-index

    2 publications

    34 citations

  4. MRC Prion Unit

    London, United Kingdom

    1 h-index

    12 publications

    300 citations

  5. University of Maryland, Baltimore

    Baltimore, United States

    1 h-index

    1 publications

    88 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    6 publications

    3.6K citations

  7. Monash University

    Melbourne, Australia

    1 h-index

    1 publications

    25 citations

  8. University of Chicago

    Chicago, United States

    1 h-index

    6 publications

    3.6K citations

1–8 of 14

Venues

  1. Journal of Visualized Experiments

    2 publications · 34 citations

    2

    h-index

  2. Cell

    1 publications · 599 citations

    1

    h-index

  3. PLoS ONE

    1 publications · 25 citations

    1

    h-index

  4. PLoS Biology

    1 publications · 25 citations

    1

    h-index

  5. Journal of Biological Chemistry

    JBC · 1 publications · 88 citations

    1

    h-index

1–5