Second Messenger Signaling is a biochemical mechanism in cell communication whereby intracellular signaling molecules, generated in response to an extracellular stimulus, relay and amplify the signal to effect specific cellular responses.
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Second Messenger System
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Adenylate Cyclase RegulationCalcium-induced Calcium ReleaseCalmodulin SignalingCamp MicrodomainsCyclic Guanosine Monophosphate SignalingDiacylglycerol SignalingInositol Phosphate SignalingPhosphatidylinositol 3, 4, 5-Trisphosphate SignalingPhosphodiesterase SignalingPhospholipase C Signaling
Publications
1.2K
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
Jen Liou, Man Lyang Kim, Won Do Heo et al. · Current Biology · 2005 · 2.1K citations · Full text
cPLA2 is phosphorylated and activated by MAP kinase
Lih‐Ling Lin, Markus Wartmann, Alice Lin et al. · Cell · 1993 · 1.9K citations
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Teresa Fernandes‐Alnemri, Je‐Wook Yu, Pinaki Datta et al. · Nature · 2009 · 1.8K citations · Full text
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text
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National Institutes of Health
Bethesda, United States
27 h-index
105 publications
13.3K citations
Howard Hughes Medical Institute
Chevy Chase, United States
22 h-index
61 publications
17.8K citations
Inserm
Paris, France
18 h-index
98 publications
5.9K citations
Harvard University
Cambridge, United States
18 h-index
47 publications
6.2K citations
University of California, San Francisco
San Francisco, United States
16 h-index
50 publications
9.5K citations
University of Cambridge
Cambridge, United Kingdom
15 h-index
33 publications
8.5K citations
The University of Tokyo
Tokyo, Japan
15 h-index
66 publications
3.9K citations
University of California San Diego
San Diego, United States
15 h-index
36 publications
5.9K citations
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- Journal of Biological Chemistry
JBC · 72 publications · 7.7K citations
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- Biochemical and Biophysical Research Communications
BBRC · 83 publications · 3.2K citations
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- Nature
25 publications · 17.3K citations
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- The EMBO Journal
25 publications · 5.5K citations
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- PubMed
Repository · 40 publications · 1.4K citations
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