Concepedia

Sec-dependent Translocation

Sec-Dependent Translocation is a protein translocation mechanism that belongs to the class of co- or post-translational secretion pathways and is distinguished by its dependence on the conserved SecYEG translocon complex and SecA ATPase to mediate the transport of unfolded polypeptides across or into cellular membranes in prokaryotes and organelles of endosymbiotic origin.

265

Publications

25.6K

Citations

851

Authors

245

Institutions

Publications per year

2017–2026

29

Variants

Sec-dependent Protein TranslocationSec-dependent Secretion

Parents

Publications

265

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Emmanuel J. H. J. Wiertz, Domenico Tortorella, Matthew Bogyo et al. · Nature · 1996 · 1.1K citations

, , +8

The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins

Roland Lill, William Dowhan, William Wickner · Cell · 1990 · 552 citations

, , +10

Prediction of twin-arginine signal peptides

Jannick Dyrløv Bendtsen, Henrik Nielsen, David A. Widdick et al. · BMC Bioinformatics · 2005 · 534 citations · Full text

, , +15

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion

Anastassios Economou, William Wickner · Cell · 1994 · 525 citations

, , +10

The purified E. coli integral membrane protein is sufficient for reconstitution of SecA-dependent precursor protein translocation

Lorna Brundage, Joseph P. Hendrick, Arnold J. M. Driessen et al. · Cell · 1990 · 516 citations

, , +11

1–5 of 265

Authors

851

  1. TA
    Tom A. Rapoport

    Harvard University, United States

    17 publications · 3.8K citations

    16

    h-index

  2. AJ
    Arnold J. M. Driessen

    University of Groningen, Netherlands

    19 publications · 1.7K citations

    16

    h-index

  3. KI
    Koreaki Ito

    Kyoto University, Japan

    16 publications · 1.5K citations

    14

    h-index

  4. HM
    Hiroyuki Mori

    Kyoto University, Japan

    13 publications · 752 citations

    11

    h-index

  5. FD
    Franck Duong

    University of British Columbia, Canada

    10 publications · 1.2K citations

    10

    h-index

1–5 of 851

Institutions

245

  1. Harvard University

    Cambridge, United States

    21 h-index

    62 publications

    7.9K citations

  2. The University of Tokyo

    Tokyo, Japan

    19 h-index

    73 publications

    7.4K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    48 publications

    6.4K citations

  4. Kyoto University

    Kyoto, Japan

    16 h-index

    47 publications

    2.3K citations

  5. University of Groningen

    Groningen, The Netherlands

    15 h-index

    62 publications

    3.8K citations

  6. Wesleyan University

    Middletown, United States

    10 h-index

    20 publications

    811 citations

  7. University of California, Los Angeles

    Los Angeles, United States

    10 h-index

    34 publications

    8.6K citations

  8. The Ohio State University

    Columbus, United States

    8 h-index

    29 publications

    1.9K citations

1–8 of 245

Venues

  1. The EMBO Journal

    30 publications · 4.5K citations

    30

    h-index

  2. Journal of Biological Chemistry

    JBC · 45 publications · 2.5K citations

    29

    h-index

  3. Journal of Bacteriology

    JB · 24 publications · 1.3K citations

    20

    h-index

  4. Cell

    14 publications · 4.1K citations

    14

    h-index

  5. Journal of Molecular Biology

    JMB · 12 publications · 557 citations

    12

    h-index

1–5