Concepedia

Scale-up Principles

Scale-Up Principles is a methodological framework that systematizes the systematic translation of laboratory-scale freeze-drying processes into larger, industrially viable operations while maintaining product quality, process efficiency, and reproducibility across different equipment and environmental conditions.

47

Publications

2.1K

Citations

188

Authors

81

Institutions

Publications per year

2017–2026

11

Parents

Publications

47

Heat and mass transfer scale-up issues during freeze drying: II. Control and characterization of the degree of supercooling

Shailaja Rambhatla, Roee Ramot, Chandan Bhugra et al. · AAPS PharmSciTech · 2004 · 239 citations · Full text

, , +13

Reverse electrodialysis with saline waters and concentrated brines: A laboratory investigation towards technology scale-up

Michele Tedesco, Etienne Brauns, Andrea Cipollina et al. · Journal of Membrane Science · 2015 · 209 citations

, , +11

Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect

Shailaja Rambhatla, Michael J. Pikal · AAPS PharmSciTech · 2003 · 184 citations · Full text

, , +16

Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes

Markus Damm, Toma Glasnov, C. Oliver Kappe · Organic Process Research & Development · 2009 · 139 citations

, , +16

Freeze drying—principles and practice for successful scale-up to manufacturing

Stelios Tsinontides, Pavol Rajniak, David K. Pham et al. · International Journal of Pharmaceutics · 2004 · 136 citations

, , +12

1–5 of 47

Authors

188

  1. SR
    Shailaja Rambhatla

    University of Connecticut, United States

    3 publications · 519 citations

    3

    h-index

  2. MJ
    Michael J. Pikal

    University of Connecticut, United States

    3 publications · 519 citations

    3

    h-index

  3. AL
    Anders Lyngfelt

    Chalmers University of Technology, Sweden

    2 publications · 62 citations

    2

    h-index

  4. ST
    Serguei Tchessalov

    Pfizer (United States), United States

    2 publications · 112 citations

    2

    h-index

  5. IK
    Ian Kemp

    GlaxoSmithKline (United Kingdom), United Kingdom

    2 publications · 50 citations

    2

    h-index

1–5 of 188

Institutions

81

  1. University of Connecticut

    Storrs, United States

    3 h-index

    9 publications

    1.6K citations

  2. Bayer (Germany)

    Leverkusen, Germany

    3 h-index

    4 publications

    67 citations

  3. Flemish Institute for Technological Research

    Mol, Belgium

    2 h-index

    4 publications

    462 citations

  4. Chalmers University of Technology

    Gothenburg, Sweden

    2 h-index

    4 publications

    124 citations

  5. Lonza (Switzerland)

    Basel, Switzerland

    2 h-index

    4 publications

    109 citations

  6. Purdue University West Lafayette

    West Lafayette, United States

    2 h-index

    3 publications

    43 citations

  7. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    2 publications

    152 citations

  8. Lundbeck (Denmark)

    Copenhagen, Denmark

    1 h-index

    3 publications

    96 citations

1–8 of 81

Venues

  1. Drying Technology

    5 publications · 139 citations

    5

    h-index

  2. AAPS PharmSciTech

    4 publications · 535 citations

    4

    h-index

  3. Chemie Ingenieur Technik

    3 publications · 62 citations

    3

    h-index

  4. Industrial & Engineering Chemistry Research

    2 publications · 37 citations

    2

    h-index

  5. Energy Procedia

    2 publications · 62 citations

    2

    h-index

1–5