Concepedia

Scaffold Flexibility Modulation

Scaffold Flexibility Modulation is a computational strategy in medicinal chemistry that systematically alters the conformational rigidity or lability of a molecular scaffold to optimize its capacity for bioactive conformation acquisition while maintaining structural novelty during scaffold hopping.

4

Publications

119

Citations

18

Authors

6

Institutions

Publications per year

2017–2026

2

Parents

Publications

4

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

Shashwati Paul, Daniel Adelfinsky, Christophe Salomé et al. · Chemical Science · 2023 · 46 citations · Full text

, , +17

Rigidification with indolocarbazole and molecular orbitals regulation by peripheral donation towards pure green polycyclo-heteraborin MR-TADF scaffolds for stable narrowband OLEDs

Paramasivam Palanisamy, Odugu Pavan Kumar, Hae Ung Kim et al. · Chemical Engineering Journal · 2024 · 39 citations

, , +12

Rational tuning of the rigidity of a ligand scaffold: synthesis of diphenylsulfide-linked bis(oxazoline) ligands and their application in asymmetric allylic alkylation

Xian Du, Han Liu, Da‐Ming Du · Tetrahedron Asymmetry · 2010 · 22 citations

, , +14

Peptide Scaffolds: Flexible Molecular Structures With Diverse Therapeutic Potentials

Radhika Deshmukh, Hemant J. Purohit · International Journal of Peptide Research and Therapeutics · 2012 · 12 citations

, , +16

Scaffold Flexibility Controls Binding of Herpes Simplex Virus Type 1 with Sulfated Dendritic Polyglycerol Hydrogels Fabricated by Thiol‐Maleimide Click Reaction

Boonya Thongrom, Antara Sharma, Chuanxiong Nie et al. · Macromolecular Bioscience · 2022 · 11 citations · Full text

, , +17

1–5 of 4

Authors

18

  1. CS
    Christophe Salomé

    Université de Strasbourg, France

    1 publications · 46 citations

    1

    h-index

  2. DD
    Da‐Ming Du

    Beijing Institute of Technology, China

    1 publications · 22 citations

    1

    h-index

  3. JB
    Ji‐Ho Baek

    Hanyang University, South Korea

    1 publications · 39 citations

    1

    h-index

  4. HJ
    Hemant J. Purohit

    National Environmental Engineering Research Institute, India

    1 publications · 12 citations

    1

    h-index

  5. JK
    JunYun Kim

    Korea University, South Korea

    1 publications · 39 citations

    1

    h-index

1–5 of 18

Institutions

6

  1. National Environmental Engineering Research Institute

    Nagpur, India

    1 h-index

    2 publications

    24 citations

  2. Beijing Institute of Technology

    Beijing, China

    1 h-index

    2 publications

    44 citations

  3. Kyung Hee University

    Seoul, South Korea

    1 h-index

    6 publications

    234 citations

  4. Peking University

    Beijing, China

    1 h-index

    1 publications

    22 citations

  5. Indiana University Bloomington

    Bloomington, United States

    1 h-index

    3 publications

    138 citations

  6. Beijing National Laboratory for Molecular Sciences

    Beijing, China

    1 h-index

    1 publications

    22 citations

  7. Freie Universität Berlin

    Berlin, Germany

    1 publications

    11 citations

1–7 of 6

Venues

  1. Chemical Engineering Journal

    1 publications · 39 citations

    1

    h-index

  2. 1

    h-index

  3. Chemical Science

    1 publications · 46 citations

    1

    h-index

  4. Tetrahedron Asymmetry

    1 publications · 22 citations

    1

    h-index

  5. Macromolecular Bioscience

    1 publications · 11 citations

1–5