Concepedia

Sac Protein Dysfunction

SAC Protein Dysfunction is a molecular pathology characterized by impaired function of spindle assembly checkpoint proteins, leading to erroneous chromosome segregation during mitosis due to failure in delaying anaphase onset until proper kinetochore-microtubule attachment is achieved.

20

Publications

623

Citations

147

Authors

62

Institutions

Publications per year

2017–2026

11

Variants

Spindle Assembly Checkpoint Protein Dysfunction

Parents

Publications

20

A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition

Sara Morais da Silva, Tatiana Moutinho‐Santos, Cláudio E. Sunkel · The Journal of Cell Biology · 2013 · 68 citations · Full text

, , +17

Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin

Emma J. Duncan, Roxanne Larivière, Teisha Y. Bradshaw et al. · Human Molecular Genetics · 2017 · 66 citations · Full text

, , +17

Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells

J. Bargiela-Iparraguirre, L Prado-Marchal, Natalia Pajuelo‐Lozano et al. · Cell Cycle · 2014 · 61 citations · Full text

, , +17

Oncogenic MYC amplifies mitotic perturbations

Samantha Littler, Olivia Sloss, Bethany Geary et al. · Open Biology · 2019 · 57 citations · Full text

, , +17

Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics

Benoît J. Gentil, Gia-Thanh Lai, Marie Ménade et al. · The FASEB Journal · 2018 · 51 citations · Full text

, , +17

1–5 of 20

Authors

147

  1. BB
    Bernard Brais

    McGill University, Canada

    4 publications · 156 citations

    4

    h-index

  2. HD
    Heather D. Durham

    McGill University, Canada

    3 publications · 131 citations

    3

    h-index

  3. BJ
    Benoît J. Gentil

    McGill University, Canada

    3 publications · 131 citations

    3

    h-index

  4. RL
    Roxanne Larivière

    McGill University, Canada

    2 publications · 117 citations

    2

    h-index

  5. JP
    J. Paul Chapple

    Queen Mary University of London, United Kingdom

    2 publications · 117 citations

    2

    h-index

1–5 of 147

Institutions

62

  1. McGill University

    Montreal, Canada

    4 h-index

    25 publications

    824 citations

  2. Montreal Neurological Institute and Hospital

    Montreal, Canada

    4 h-index

    26 publications

    912 citations

  3. Queen Mary University of London

    London, United Kingdom

    2 h-index

    7 publications

    447 citations

  4. William Harvey Research Institute

    London, United Kingdom

    2 h-index

    7 publications

    447 citations

  5. Universidad Autónoma de Madrid

    Madrid, Spain

    2 h-index

    7 publications

    381 citations

  6. Spanish National Cancer Research Centre

    Madrid, Spain

    2 h-index

    16 publications

    228 citations

  7. Helmholtz Zentrum München

    Munich, Germany

    1 h-index

    1 publications

    22 citations

  8. Vita-Salute San Raffaele University

    Milan, Italy

    1 h-index

    2 publications

    132 citations

1–8 of 62

Venues

  1. Cell Cycle

    2 publications · 73 citations

    2

    h-index

  2. Journal of Cell Science

    1 publications · 13 citations

    1

    h-index

  3. Life Science Alliance

    LSA · 1 publications · 22 citations

    1

    h-index

  4. Oncotarget

    1 publications · 40 citations

    1

    h-index

  5. PLoS ONE

    1 publications · 37 citations

    1

    h-index

1–5