Concepedia

Resistance Mutation Interpretation

Resistance Mutation Interpretation is a computational and analytical framework within somatic variant interpretation that identifies and characterizes acquired genetic alterations in cancer cells responsible for conferring resistance to targeted therapies, distinguishing itself by its focus on predicting therapeutic failure and guiding subsequent treatment strategies.

62

Publications

4.1K

Citations

549

Authors

243

Institutions

Publications per year

2017–2026

21

Parents

Publications

62

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

Shunqiang Li, Dong Shen, Jieya Shao et al. · Cell Reports · 2013 · 625 citations · Full text

, , +14

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

Jody Phelan, Denise M. O’Sullivan, Diana Machado et al. · Genome Medicine · 2019 · 537 citations · Full text

, , +17

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson et al. · Cancer Cell · 2015 · 420 citations · Full text

, , +11

Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain

Simona Soverini, Sabrina Colarossi, Alessandra Gnani et al. · Haematologica · 2007 · 190 citations · Full text

, , +11

Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)

Nikolas von Bubnoff, Paul W. Manley, Jürgen Mestan et al. · Blood · 2006 · 164 citations · Full text

, , +17

1–5 of 62

Authors

549

  1. TG
    Therese Giuntoli

    UNC Lineberger Comprehensive Cancer Center

    2 publications · 653 citations

    2

    h-index

  2. JH
    Jeffrey Hiken

    Washington University in St. Louis, United States

    2 publications · 653 citations

    2

    h-index

  3. GB
    Gordon B. Mills

    The University of Texas MD Anderson Cancer Center, United States

    2 publications · 653 citations

    2

    h-index

  4. RS
    Rama Suresh

    Washington University in St. Louis, United States

    2 publications · 653 citations

    2

    h-index

  5. CC
    Crystal Cooper

    The University of Texas Southwestern Medical Center, United States

    2 publications · 653 citations

    2

    h-index

1–5 of 549

Institutions

243

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    5 h-index

    18 publications

    2.5K citations

  2. Johns Hopkins University

    Baltimore, United States

    5 h-index

    17 publications

    904 citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    4 h-index

    7 publications

    2.6K citations

  4. University of Washington

    Seattle, United States

    4 h-index

    4 publications

    136 citations

  5. University of Michigan

    Ann Arbor, United States

    3 h-index

    7 publications

    1.5K citations

  6. Stanford University

    Stanford, United States

    3 h-index

    24 publications

    5.9K citations

  7. Foundation Medicine (United States)

    Cambridge, United States

    2 h-index

    9 publications

    620 citations

  8. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    2 h-index

    2 publications

    86 citations

1–8 of 243

Venues

  1. Lung Cancer

    4 publications · 173 citations

    4

    h-index

  2. Journal of Molecular Diagnostics

    JMD · 3 publications · 159 citations

    3

    h-index

  3. Journal of Antimicrobial Chemotherapy

    JAC · 3 publications · 149 citations

    3

    h-index

  4. AIDS

    3 publications · 212 citations

    3

    h-index

  5. PLoS ONE

    3 publications · 115 citations

    3

    h-index

1–5