Concepedia

Replication-defective Vectors

Replication-Defective Vectors is a type of viral vector engineered to retain the ability to deliver genetic material into host cells but lacks essential genes required for viral replication, thereby preventing the production of new infectious virions.

400

Publications

31.7K

Citations

2.1K

Authors

504

Institutions

Publications per year

2017–2026

10

Variants

Replication-incompetent Vectors

Parents

Publications

400

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

Mohammed Adam, A. Dusty Miller · Molecular and Cellular Biology · 1990 · 1.4K citations · Full text

, , +14

A safe packaging line for gene transfer: separating viral genes on two different plasmids

Dina Markowitz, Stephen P. Goff, A Bank · Journal of Virology · 1988 · 1.1K citations · Full text

, , +17

Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors

Sandeep K. Tripathy, Hugh B. Black, Eugene Goldwasser et al. · Nature Medicine · 1996 · 633 citations

, , +17

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

Richard R. Spaete · Cell · 1982 · 508 citations

, , +10

New Helper Cells and Matched Early Region 1-Deleted Adenovirus Vectors Prevent Generation of Replication-Competent Adenoviruses

Frits J. Fallaux, A. Bout, Ietje van der Velde et al. · Human Gene Therapy · 1998 · 477 citations

, , +14

1–5 of 400

Authors

2.1K

  1. JC
    Joseph C. Glorioso

    University of Pittsburgh, United States

    12 publications · 528 citations

    11

    h-index

  2. JM
    James M. Wilson

    University of Pennsylvania, United States

    7 publications · 871 citations

    7

    h-index

  3. WF
    William F. Goins

    University of Pittsburgh, United States

    7 publications · 245 citations

    7

    h-index

  4. HC
    Hildegund C.J. Ertl

    The Wistar Institute, United States

    6 publications · 594 citations

    6

    h-index

  5. KE
    Kenneth E. Drazan

    University of California, Los Angeles, United States

    6 publications · 233 citations

    6

    h-index

1–5 of 2.1K

Institutions

504

  1. University of Pittsburgh

    Pittsburgh, United States

    20 h-index

    102 publications

    5.5K citations

  2. Harvard University

    Cambridge, United States

    18 h-index

    80 publications

    13K citations

  3. National Institutes of Health

    Bethesda, United States

    15 h-index

    84 publications

    12.5K citations

  4. University of Pennsylvania

    Philadelphia, United States

    13 h-index

    57 publications

    5.4K citations

  5. University of Wisconsin–Madison

    Madison, United States

    12 h-index

    23 publications

    960 citations

  6. National Cancer Institute

    Bethesda, United States

    12 h-index

    44 publications

    3.9K citations

  7. Massachusetts General Hospital

    Boston, United States

    10 h-index

    26 publications

    4.4K citations

  8. The Wistar Institute

    Philadelphia, United States

    10 h-index

    42 publications

    5.3K citations

1–8 of 504

Venues

  1. Journal of Virology

    JVI · 65 publications · 6.6K citations

    41

    h-index

  2. Human Gene Therapy

    38 publications · 2.8K citations

    29

    h-index

  3. PubMed

    Repository · 38 publications · 2.3K citations

    25

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.7K citations

    16

    h-index

  5. Molecular Therapy

    16 publications · 1.3K citations

    15

    h-index

1–5