Concepedia

Repeat Protein Design

Repeat Protein Design is a protein engineering methodology that involves the rational construction of tandem structural repeats within a polypeptide sequence to achieve desired stability, foldability, and functional properties, distinguished from other protein design approaches by its reliance on repetitive architectural motifs derived from naturally occurring repeat proteins.

51

Publications

3.7K

Citations

252

Authors

80

Institutions

Publications per year

2017–2026

15

Parents

Publications

51

Designing Repeat Proteins: Well-expressed, Soluble and Stable Proteins from Combinatorial Libraries of Consensus Ankyrin Repeat Proteins

Hans Binz, Michael T. Stumpp, Patrik Forrer et al. · Journal of Molecular Biology · 2003 · 585 citations

, , +16

Exploring the repeat protein universe through computational protein design

TJ Brunette, Fabio Parmeggiani, Po‐Ssu Huang et al. · Nature · 2015 · 279 citations · Full text

, , +14

A Designed Ankyrin Repeat Protein Evolved to Picomolar Affinity to Her2

Christian Zahnd, Emanuel Wyler, Jochen M. Schwenk et al. · Journal of Molecular Biology · 2007 · 254 citations

, , +12

A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end

Ludovic Pecqueur, Christian Duellberg, Birgit Dreier et al. · Proceedings of the National Academy of Sciences · 2012 · 160 citations

, , +17

A novel strategy to design binding molecules harnessing the modular nature of repeat proteins

Patrik Forrer, Michael T. Stumpp, Hans Binz et al. · FEBS Letters · 2003 · 149 citations

, , +17

1–5 of 51

Authors

252

  1. AP
    Andreas Plückthun

    University of Zurich, Switzerland

    22 publications · 2.1K citations

    16

    h-index

  2. PR
    Peer R. E. Mittl

    University of Zurich, Switzerland

    9 publications · 254 citations

    9

    h-index

  3. DB
    David Baker

    University of Washington, United States

    8 publications · 749 citations

    8

    h-index

  4. FP
    Fabio Parmeggiani

    University of Washington, United States

    7 publications · 762 citations

    7

    h-index

  5. MG
    Markus G. Grütter

    University of Zurich, Switzerland

    6 publications · 276 citations

    6

    h-index

1–5 of 252

Institutions

80

  1. University of Zurich

    Zurich, Switzerland

    16 h-index

    135 publications

    10.8K citations

  2. University of Washington

    Seattle, United States

    9 h-index

    51 publications

    3.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    9 publications

    760 citations

  4. Fred Hutch Cancer Center

    Seattle, United States

    4 h-index

    19 publications

    1K citations

  5. Yale University

    New Haven, United States

    3 h-index

    10 publications

    679 citations

  6. CIC biomaGUNE

    Donostia / San Sebastian, Spain

    2 h-index

    8 publications

    203 citations

  7. North Seattle College

    Seattle, United States

    2 h-index

    11 publications

    155 citations

  8. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    11 publications

    179 citations

1–8 of 80

Venues

  1. Journal of Molecular Biology

    JMB · 11 publications · 1.5K citations

    11

    h-index

  2. Nature

    3 publications · 487 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 264 citations

    3

    h-index

  4. Protein Science

    PS · 3 publications · 69 citations

    3

    h-index

  5. Scientific Reports

    2 publications · 43 citations

    2

    h-index

1–5