Concepedia

Recombinant Thrombomodulin

Recombinant Thrombomodulin is a biopharmaceutical agent belonging to the class of anticoagulant proteins, distinguished by its engineered production through recombinant DNA technology to replicate the functional domains of human thrombomodulin for modulating coagulation and inflammation in disseminated intravascular coagulation.

296

Publications

14K

Citations

1.7K

Authors

472

Institutions

Publications per year

2017–2026

63

Variants

Art-123Thrombomodulin Alfa

Parents

Publications

296

Efficacy and safety of recombinant human soluble thrombomodulin (ART‐123) in disseminated intravascular coagulation: results of a phase III, randomized, double‐blind clinical trial

Hiroaki Saito, Ikuro Maruyama, S Shimazaki et al. · Journal of Thrombosis and Haemostasis · 2006 · 600 citations

, , +11

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.

Steven R. Lentz, J. Evan Sadler · Journal of Clinical Investigation · 1991 · 452 citations · Full text

, , +17

New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey

Toshiaki Iba, Marcello Di Nisio, Jerrold H. Levy et al. · BMJ Open · 2017 · 427 citations · Full text

, , +14

“Normal” Thrombin Generation

Saulius Butenas, Cornelis van’t Veer, Kenneth G. Mann · Blood · 1999 · 381 citations

, , +17

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy

Jean‐Louis Vincent, Bruno François, Mradul Kumar Daga et al. · JAMA · 2019 · 370 citations · Full text

, , +15

1–5 of 296

Authors

1.7K

  1. IM
    Ikuro Maruyama

    Kagoshima University, Japan

    22 publications · 1.7K citations

    18

    h-index

  2. GH
    Goichi Honda

    Asahi Kasei (Japan), Japan

    14 publications · 574 citations

    13

    h-index

  3. CT
    Charles T. Esmon

    Oklahoma Medical Research Foundation, United States

    13 publications · 1.2K citations

    13

    h-index

  4. JM
    John Morser

    Stanford University, United States

    12 publications · 504 citations

    12

    h-index

  5. KG
    K Gomi

    Kagoshima University, Japan

    12 publications · 471 citations

    11

    h-index

1–5 of 1.7K

Institutions

472

  1. Asahi Kasei (Japan)

    Tokyo, Japan

    19 h-index

    61 publications

    3.4K citations

  2. Kagoshima University

    Kagoshima, Japan

    18 h-index

    58 publications

    4.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    45 publications

    3.1K citations

  4. Eli Lilly (United States)

    Indianapolis, United States

    12 h-index

    36 publications

    1.7K citations

  5. Oklahoma Medical Research Foundation

    Oklahoma City, United States

    12 h-index

    29 publications

    1.8K citations

  6. The University of Osaka

    Osaka, Japan

    12 h-index

    54 publications

    3.1K citations

  7. Tokyo Medical and Dental University

    Tokyo, Japan

    11 h-index

    28 publications

    1.5K citations

  8. Tohoku University

    Sendai, Japan

    10 h-index

    44 publications

    1.4K citations

1–8 of 472

Venues

  1. Journal of Biological Chemistry

    JBC · 24 publications · 1.8K citations

    23

    h-index

  2. Thrombosis and Haemostasis

    19 publications · 864 citations

    16

    h-index

  3. Thrombosis Research

    13 publications · 371 citations

    12

    h-index

  4. Clinical and Applied Thrombosis/Hemostasis

    CATH · 7 publications · 166 citations

    7

    h-index

  5. Blood

    7 publications · 465 citations

    7

    h-index

1–5