Concepedia

Ras Structure-function Relationships

RAS Structure-Function Relationships is a theoretical construct in molecular oncology that elucidates how the three-dimensional conformation and biochemical properties of RAS proteins govern their signaling activities, regulatory mechanisms, and oncogenic potential.

525

Publications

51.2K

Citations

2.2K

Authors

574

Institutions

Publications per year

2017–2026

64

Parents

Publications

525

Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

E.F. Pai, Ute Krengel, Gregory A. Petsko et al. · The EMBO Journal · 1990 · 1.1K citations · Full text

, , +14

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic <i>ras</i> Proteins

Michael V. Milburn, Liang Tong, Abraham M. deVos et al. · Science · 1990 · 1.1K citations

, , +17

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

Shonna A. Moodie, Berthe M. Willumsen, Michael J. Weber et al. · Science · 1993 · 986 citations

, , +15

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

E.F. Pai, Wolfgang Kabsch, Ute Krengel et al. · Nature · 1989 · 889 citations

, , +12

An essential role for Rac in Ras transformation

Rongguo Qiu, Jing Chen, David H. Kirn et al. · Nature · 1995 · 885 citations

, , +7

1–5 of 525

Authors

2.2K

  1. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    23 publications · 2.8K citations

    22

    h-index

  2. AW
    Alfred Wittinghofer

    Max Planck Institute of Molecular Physiology, Germany

    20 publications · 3.5K citations

    19

    h-index

  3. FM
    Frank McCormick

    University of California, San Francisco, United States

    15 publications · 2.7K citations

    15

    h-index

  4. TK
    Tohru Kataoka

    Kobe University, Japan

    15 publications · 1.9K citations

    15

    h-index

  5. CH
    Christian Herrmann

    Ruhr University Bochum, Germany

    13 publications · 2.1K citations

    13

    h-index

1–5 of 2.2K

Institutions

574

  1. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    28 h-index

    108 publications

    13.4K citations

  2. Max Planck Society

    Munich, Germany

    22 h-index

    98 publications

    18K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    22 h-index

    97 publications

    10.6K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    20 h-index

    63 publications

    11.3K citations

  5. National Cancer Institute

    Bethesda, United States

    20 h-index

    82 publications

    7K citations

  6. University of California, Berkeley

    Berkeley, United States

    16 h-index

    64 publications

    13.1K citations

  7. Lawrence Berkeley National Laboratory

    Berkeley, United States

    15 h-index

    52 publications

    13.8K citations

  8. Kobe University

    Kobe, Japan

    14 h-index

    93 publications

    10.4K citations

1–8 of 574

Venues

  1. Journal of Biological Chemistry

    JBC · 91 publications · 7.8K citations

    53

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 39 publications · 6.8K citations

    35

    h-index

  3. Molecular and Cellular Biology

    MCB · 56 publications · 5.1K citations

    34

    h-index

  4. PubMed

    Repository · 26 publications · 1.6K citations

    20

    h-index

  5. Biochemistry

    19 publications · 955 citations

    16

    h-index

1–5