Concepedia

Ras Post-translational Modification

RAS Post-Translational Modification is a biochemical process that constitutes the covalent attachment of specific functional groups to RAS proteins after their synthesis, thereby enabling membrane localization and activation within the signaling pathways governing cell proliferation and survival.

290

Publications

30.4K

Citations

1.2K

Authors

327

Institutions

Publications per year

2017–2026

26

Parents

Publications

290

All ras proteins are polyisoprenylated but only some are palmitoylated

John F. Hancock, Anthony I. Magee, Julie E. Childs et al. · Cell · 1989 · 1.8K citations

, , +6

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

David B. Whyte, Paul T. Kirschmeier, Tish Hockenberry et al. · Journal of Biological Chemistry · 1997 · 881 citations · Full text

, , +16

p21ras is modified by a farnesyl isoprenoid.

Patrick J. Casey, Patricia A. Solski, Channing J. Der et al. · Proceedings of the National Academy of Sciences · 1989 · 855 citations · Full text

, , +12

An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

Oliver Rocks, Anna Peyker, Martin Kahms et al. · Science · 2005 · 853 citations

, , +17

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Tod Smeal, Bernard Binétruy, Daniel A. Mercola et al. · Nature · 1991 · 800 citations

, , +14

1–5 of 290

Authors

1.2K

  1. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    21 publications · 3.6K citations

    19

    h-index

  2. JE
    Janice E. Buss

    Iowa State University, United States

    15 publications · 2.6K citations

    15

    h-index

  3. AD
    Adrienne D. Cox

    University of North Carolina at Chapel Hill, United States

    12 publications · 1.7K citations

    12

    h-index

  4. HW
    Herbert Waldmann

    Max Planck Institute of Molecular Physiology, Germany

    11 publications · 1.3K citations

    11

    h-index

  5. RJ
    Robert J. Deschenes

    University of Iowa, United States

    10 publications · 2K citations

    10

    h-index

1–5 of 1.2K

Institutions

327

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    17 h-index

    71 publications

    7.4K citations

  2. University of Iowa

    Iowa City, United States

    13 h-index

    37 publications

    5.1K citations

  3. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    12 h-index

    48 publications

    10.1K citations

  4. United States Military Academy

    West Point, United States

    11 h-index

    53 publications

    13.4K citations

  5. New York University

    New York, United States

    9 h-index

    31 publications

    2.9K citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    8 h-index

    28 publications

    6.8K citations

  7. National Cancer Institute

    Bethesda, United States

    8 h-index

    23 publications

    3.6K citations

  8. Kobe University

    Kobe, Japan

    8 h-index

    53 publications

    4.7K citations

1–8 of 327

Venues

  1. Journal of Biological Chemistry

    JBC · 57 publications · 8.2K citations

    46

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 3.8K citations

    19

    h-index

  3. Molecular and Cellular Biology

    MCB · 19 publications · 1.7K citations

    19

    h-index

  4. PubMed

    Repository · 19 publications · 1.5K citations

    17

    h-index

  5. Science

    8 publications · 3K citations

    8

    h-index

1–5