Concepedia

Rag1-rag2 Complex Function

The "RAG1-RAG2 Complex Function" is a molecular mechanism in adaptive immunity that belongs to the class of site-specific recombinase systems, distinguished by its catalytic role in initiating V(D)J recombination through the recognition and cleavage of recombination signal sequences at antigen receptor gene loci.

64

Publications

3.9K

Citations

262

Authors

111

Institutions

Publications per year

2017–2026

7

Parents

Publications

64

RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination

Alka Agrawal, David G. Schatz · Cell · 1997 · 296 citations · Full text

, , +16

The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci

Yanhong Ji, Wolfgang Resch, Elizabeth Corbett et al. · Cell · 2010 · 289 citations · Full text

, , +11

A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

Sathees C. Raghavan, Patrick C. Swanson, Xiantuo Wu et al. · Nature · 2004 · 241 citations

, , +15

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

Heng Ru, Melissa G. Chambers, Tian‐Min Fu et al. · Cell · 2015 · 203 citations · Full text

, , +11

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Kuang Shen, Rick Huang, Edward J. Brignole et al. · Nature · 2018 · 185 citations

, , +9

1–5 of 64

Authors

262

  1. DG
    David G. Schatz

    Yale University, United States

    14 publications · 1.2K citations

    12

    h-index

  2. PC
    Patrick C. Swanson

    CHI Health Creighton University Medical Center - Bergan Mercy, United States

    6 publications · 419 citations

    6

    h-index

  3. MA
    Marjorie A. Oettinger

    Massachusetts General Hospital, United States

    4 publications · 338 citations

    4

    h-index

  4. MR
    Michael R. Lieber

    University of Southern California, United States

    4 publications · 385 citations

    4

    h-index

  5. SD
    Sebastian D. Fugmann

    Howard Hughes Medical Institute, United States

    4 publications · 463 citations

    4

    h-index

1–5 of 262

Institutions

111

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    44 publications

    4.8K citations

  2. Yale University

    New Haven, United States

    13 h-index

    34 publications

    3.1K citations

  3. National Institutes of Health

    Bethesda, United States

    7 h-index

    32 publications

    1.7K citations

  4. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    4 h-index

    15 publications

    416 citations

  5. USC Norris Comprehensive Cancer Center

    Los Angeles, United States

    4 h-index

    6 publications

    486 citations

  6. Harvard University

    Cambridge, United States

    4 h-index

    18 publications

    2.1K citations

  7. CHI Health Creighton University Medical Center - Bergan Mercy

    Omaha, United States

    4 h-index

    10 publications

    246 citations

  8. Massachusetts General Hospital

    Boston, United States

    4 h-index

    11 publications

    907 citations

1–8 of 111

Venues

  1. Molecular and Cellular Biology

    MCB · 11 publications · 750 citations

    11

    h-index

  2. Journal of Biological Chemistry

    JBC · 5 publications · 152 citations

    5

    h-index

  3. Cell

    5 publications · 809 citations

    5

    h-index

  4. Molecular Cell

    5 publications · 469 citations

    5

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 326 citations

    4

    h-index

1–5