Concepedia

Proteolysis Reduction

Proteolysis Reduction is a methodological strategy in protein expression optimization that specifically diminishes the degradation of expressed proteins by endogenous proteolytic enzymes to enhance yield and stability.

164

Publications

10.5K

Citations

769

Authors

275

Institutions

Publications per year

2017–2026

23

Parents

Publications

164

NARC-1/PCSK9 and Its Natural Mutants

Suzanne Benjannet, David Rhainds, Rachid Essalmani et al. · Journal of Biological Chemistry · 2004 · 625 citations · Full text

, , +17

PROTEINASE MUTANTS OF <i>SACCHAROMYCES CEREVISIAE</i>

Elizabeth W. Jones · Genetics · 1977 · 457 citations · Full text

, , +14

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

Nicholas E. Tawa, Richard Odessey, Alfred L. Goldberg · Journal of Clinical Investigation · 1997 · 317 citations · Full text

, , +17

An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability

M. Whitlow, Brian Bell, Sheau-Line Feng et al. · Protein Engineering Design and Selection · 1993 · 311 citations

, , +12

Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture.

Helene Sage, Charles M. Johnson, Paul Börnstein · Journal of Biological Chemistry · 1984 · 267 citations · Full text

, , +11

1–5 of 164

Authors

769

  1. AL
    Alfred L. Goldberg

    Harvard University, United States

    4 publications · 824 citations

    4

    h-index

  2. IE
    Ilsebill Eckle

    Philipps University of Marburg, Germany

    2 publications · 92 citations

    2

    h-index

  3. PJ
    Peter J. I. van de Vondervoort

    Wageningen University & Research, Netherlands

    2 publications · 129 citations

    2

    h-index

  4. FD
    Frank Dombrowski

    Universitätsmedizin Greifswald, Germany

    2 publications · 98 citations

    2

    h-index

  5. RA
    Robin A. Wallace

    University of Florida, United States

    2 publications · 139 citations

    2

    h-index

1–5 of 769

Institutions

275

  1. Harvard University

    Cambridge, United States

    7 h-index

    28 publications

    3.3K citations

  2. University of Toronto

    Toronto, Canada

    3 h-index

    10 publications

    588 citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    9 publications

    902 citations

  4. National Institutes of Health

    Bethesda, United States

    3 h-index

    12 publications

    1.8K citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    6 publications

    251 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    15 publications

    952 citations

  7. Inserm

    Paris, France

    3 h-index

    10 publications

    3.2K citations

  8. State Key Laboratory of Food Science and Technology

    Wuxi, China

    2 h-index

    9 publications

    337 citations

1–8 of 275

Venues

  1. Journal of Biological Chemistry

    JBC · 27 publications · 2.8K citations

    25

    h-index

  2. European Journal of Biochemistry

    EJB · 7 publications · 372 citations

    7

    h-index

  3. Biochemical Journal

    BJ · 6 publications · 435 citations

    6

    h-index

  4. 4

    h-index

  5. FEBS Journal

    3 publications · 50 citations

    3

    h-index

1–5